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| 基于多因子降维法模型的醛固酮合成酶基因多态性与饮酒指数对蒙古族人群高血压的交互作用 | |
| 引用本文： | 潘兴强,刘永跃,张显玉,张永红,许群,邱长春,佟伟军. 基于多因子降维法模型的醛固酮合成酶基因多态性与饮酒指数对蒙古族人群高血压的交互作用[J]. 中华流行病学杂志, 2009, 30(9): 955-959. DOI: 10.3760/cma.j.issn.0254-6450.2009.09.023 |
| 作者姓名： | 潘兴强 刘永跃 张显玉 张永红 许群 邱长春 佟伟军 |
| 作者单位： | 1. 苏州大学医学部放射医学与公共卫生学院流行病与卫生统计学教研室,215123 2. 内蒙古自治区通辽市疾病预防控制中心 3. 奈曼旗疾病预防控制中心 4. 中国医学科学院基础医学研究所 |
| 摘 要： | 为10/10.多因素logistic回归分析显示CYP11B2基因、饮酒指数主效应差异均无统计学意义,交互作用有统计学意义(P=0.003),其OR值及95%CI为10.25(2.23～47.18),联合作用也有统计学意义(P<0.05).结论 CYP11B2基因T(-344)C突变型与饮酒行为可能协同影响蒙古族人群高血压的发生. |
| 关 键 词： | 高血压 多因子降维法 醛固酮合成酶 饮酒指数 交互作用 |
| 收稿时间： | 2009-03-14 |
| 修稿时间： | 2007-05-22 |
Impact of gene-environment interaction between the C (-344) T polymorphism of CYP11B2 and drinking index on the risk of hypertension under multifactor dimensionality reduction model in Chinese Mongolian population |
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| PAN Xingqiang,LIU Yongyue,ZHANG Xianyu,ZHANG Yonghong,XU Qun,QIU Changchun and TONG Weijun. Impact of gene-environment interaction between the C (-344) T polymorphism of CYP11B2 and drinking index on the risk of hypertension under multifactor dimensionality reduction model in Chinese Mongolian population[J]. Chinese Journal of Epidemiology, 2009, 30(9): 955-959. DOI: 10.3760/cma.j.issn.0254-6450.2009.09.023 | |
| Authors: | PAN Xingqiang LIU Yongyue ZHANG Xianyu ZHANG Yonghong XU Qun QIU Changchun TONG Weijun |
| Affiliation: | Department of Epidemiology, School of Radiation and Public Health. Soochow University. Suzhou 2l5l23, China;Department of Epidemiology, School of Radiation and Public Health. Soochow University. Suzhou 2l5l23, China;Department of Epidemiology, School of Radiation and Public Health. Soochow University. Suzhou 2l5l23, China |
| Abstract: | 1.22-4.56), 2.05(1.07-3.94) and 5.56(2.54-12.18) respectively. Conclusion Essential hypertension might positively be affected by the interaction of the C (-344) T polymorphism of CYP11B2 and the drinking index in Chinese Mongolian population. |
| Keywords: | Hypertension Multifactor dimensionality reduction CYP11B2 Drinking index Interaction |
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