脑卒中患者神经功能缺损程度与既往高血压治疗行为的关系

背景有关高血压与脑卒中之间的关系以及血压高低对脑卒中发病率影响的研究比较多见,而高血压的治疗情况与脑卒中起病后的神经功能缺损程度方面的研究还未广泛开展.目的探讨高血压脑卒中患者卒中后神经功能缺损程度与既往高血压治疗情况之间的关系.设计病例对照研究.地点和对象选择复旦大学附属上海市第五人民医院急诊科高血压脑卒中患者,非高血压脑卒中患者及蛛网膜下腔出血患者不属于研究对象.根据其既往高血压治疗情况将研究对象分为持续治疗组(82例)、间断治疗组(95例)与无治疗组(103例).主要观察指标观察各组患者的神经功能缺损程度、脑卒中类型的构成.结果间断治疗组、无治疗组与持续治疗组相比,神经功能缺损程度较重,脑出血较多见(P均＜0.0001).结论规则的抗高血压治疗有望减少高血压性脑卒中尤其是脑出血的发生、减轻脑卒中的病情.因此,有必要采取措施使更多的高血压患者接受规则的抗高血压治疗.

Relationship betweendefect level of neural functions and previous treatment of hypertension in patients withstroke

BACKGROUND:There are quite a number of researches on the relationship between hypertension and stroke as well as the effects of blood pressure to the incidence of stroke. However, the research on the treatment of hypertension and neural function defects post stroke is limited.OBJECTIVE: To explore the relationship between the defects of neural functions in patients with stroke and the previous treatment of hypertension.DESIGN:Retrospective non-randomized case control study.SETTING and PARTICIPANTS:Patients with stroke due to hypertension were selected from the Department of Emergency, Affiliate Fifth Hospital of Fudan University,Whereas patients with non-hypertensive stroke and sub arachnoid hemorrhage were exclusive. Participants were divided into continuous treatment group(82 cases), intermitted treatment group(95 cases) and no treatment group( 103 cases).MAIN OUTCOME MEASURES:Defect level of neural functions of each group,types of stroke.RESULTS:When compared intermitted treatment group, no treatment group with continuous treatment group,the defect of neural functions were more severe and there were more cerebral hemorrhage cases comparatively( P<0.001).CONCLUSION: Regular antihypertensive treatment can reduce the incidence of stroke which relates to hypertension especially cerebral hemorrhage and relieve the conditions of patients. Therefore, it is necessary to take measures to let more patients with hypertension take the regular antihypertensive treatment.