量化运动及饮食对代谢综合征干预疗效观察

目的观察生活方式对代谢综合征（MS）发病率的影响，探讨量化运动及饮食干预对代谢综合征的疗效。方法以2008年1月至2009年12月进入深圳市慢性病防治中心健康体检的人群作为观察对象，选取有效观察对象256例，根据生活方式、工作劳动强度、身体活动问卷调查将观察对象分成积极运动生活方式组及静坐生活方式组，分析不同运动、生活方式对MS患病率的影响。选取新发现MS患者58例，随机分为运动饮食干预组（A组）29例，采取运动、饮食干预联合基础药物治疗；基础药物干预组（B组）29例，仅采取基础药物治疗。两组病例分别于干预前、干预后3个月和6个月检测体重指数、血压、血糖、血脂，观察两组干预疗效。结果积极运动生活方式组MS发病率为12．3％，明显低于静坐生活方式组的31．0％。量化饮食运动干预组患者体重指数下降明显，其3个月、6个月MS控制达标率分别为86．2％和93．1％，明显高于基础药物干预组的69．0％和82．8％（P〈0．05）。结论积极运动是MS的保护因素。多食少动的生活方式是MS发生的不良因素，加强健康教育，改变不健康生活方式，可有效预防MS的发生。运动饮食干预治疗能有效改善胰岛素敏感性，增强MS疗效。

Intervention effect of exercise and diet in the metabolic syndrome

Objective To investigate the influence of life style on incidence of the metabolic syndrome （MS）, to explore the effect of exercise and diet intervention on the metabolic syndrome. Methods 256 employees who taken health examination from January 2008 to December 2009 in Shenzhen center of chronic disease control were divided into the active lifestyle group and the sedentary lifestyle group based on their lifestyle, intensity of labor and questionnaire of physical activity. The influence of lifestyle on incidence of MS were analysised. 58 new patients with MS were randomly divided into the based therapy group that 29 patients taken basic medical treatment and the intervention group who were taken based therapy combined with exercise and diet intervention. 50 healthy adults were taken as control group. The body mass index, blood pressure, blood glucose, blood lipid of the three groups were observed and compared before intervention, 3 months and 6 months after intervention. Results The incidence of MS in the sedentary lifestyle group were 31.0%, was higher than the active lifestyle group 12.3%（P〈 0.05 ）. The body mass index of in the intervention group decreased significantly than the based therapy group （P〈 0.05）. The control rates after intervention 3 months and 6 months were 86.2%, 93.1% respectively in intervention group, were higher than based therapy group 69.0%, 82.8% respectively （P〈0.05）. Conclusion Active exercise lifestyle is one of the protective factors for MS, the lack of exercise and sedentary lifestyle is one of risk factors for MS. Strengthen the health care education and change the unhealthy styles of living can efficiency reduce incidence of MS. Exercise and diet intervention treatment can effectively improve insulin sensitivity. It shows that exercise and diet intervention can strengthen the treatment effect on MS.