"三层次学说"与鼻高反应性的相关性研究

目的验证"三层次学说"的病理生理学基础.方法将变应性鼻炎按中医的肺虚、脾虚、肾虚,分为三组即三层次.肺虚组43例、脾虚组36例、肾虚组22例,正常组96例.用组胺检测鼻高反应性和检测鼻分泌物中NO含量.结果鼻高反应性肾虚组＞脾虚组(P＜0.001)＞肺虚组(P＜0.001)＞正常组(P＜0.001),组胺剂量在各组均数分别是0.020.030.05;0.34.鼻分泌物中NO含量脾虚组(83.8±1.32)＞肺虚组(80.2±2.66)(P＜0.01)＞正常组(75.1±1.85)(P＜0.001),肾虚组与脾虚组无显著差异.结论中医将"鼻鼽"分为肺虚、脾虚、肾虚三个不同阶段(或不同类型)随病变上、中、下三焦深入,有其更深更广的病理生理损害,研究结果在临床分型和辨证论治上有指导意义.

Study of Correlation between the Three Stratification Theory and Nasal Hyperreactivity

Objective: To investigate pathophysical basis of the Three Stratification Theory. Method: Allergic rhinitis are divided into three groups according to the deficiency syndrome of lung, spleen and kidney in traditional chinese medicine. The control group was normal people. Nasal hyperreactivity (NH) and NO content in nasal secretion were tested. Result: A significant difference (p<0.001) was found in NH between the kidney group and the spleen group; the spleen group and the lung group; the lung group and the normal group (histamine concentration: the kidney group 0.02; the spleen group 0.03; the lung group 0.05; the normal group 0.34). A significant difference was found in the content of NO in nasal secretiou between the spleen group and the lung group (p<0.01); the lung group and normal group (p<0.001).There was no remarkable difference between the spleen group and the kidney group; Conclusion: There is the pathophysical basis in allergic rhinitis according to the deficiency syndrome of lung, spleen and kidney. As the disease develops, there could be deaper and wider pathophysical damages in the patients. The results of this study may be used to assist the clinic typing, diagnosis and treatment of allergic rhinitis based on overall analyses of the symptoms and signs of patients.