DNA甲基化在肝脏再生中的研究现状与展望

目的总结目前DNA甲基化与肝脏再生关系的研究现状。方法检索国内外相关文献,对肝细胞甲基化水平、基因表达调控、甲基化相关蛋白与肝脏再生关系的研究进行综述。结果 DNA甲基化作为生物体内一种重要的表观遗传调控方式,近年来在肝脏再生中的作用越来越被重视。现有的研究已经发现,在肝脏再生过程中存在基因组低甲基化、相关增殖基因甲基化改变以及DNA甲基化转移酶、含植物同源结构域和环指结构域泛素样蛋白1调控肝脏再生等表观遗传现象。结论 DNA甲基化与肝脏再生之间存在着诸多的联系,从DNA甲基化水平调节肝脏再生有望在不久的将来成为现实。

Research status and prospect of DNA methylation in liver regeneration

Objective To summarize the current research status of the relationship between DNA methylation and liver regeneration.Method The related literatures at home and abroad were searched to review the studies on relationships between the methylation level of liver cells,regulation of gene expression,and methylation related proteins and liver regeneration.Results The DNA methylation was an important epigenetic regulation method in vivo and its role in the liver regeneration had been paid more and more attentions in recent years.The existing studies had found the epigenetic phenomena during the liver regeneration such as the genomic hypomethylation,methylation changes of related proliferating genes and DNA methyltransferase and UHRF1 regulation of the liver regeneration.Conclusions There are many relationships between DNA methylation and liver regeneration.Regulation of liver regeneration from DNA methylation level is expected to become a reality in the near future.