胃肠间质瘤肝转移的治疗

目的总结现阶段胃肠间质瘤(gastrointestinal stromal tumor,GIST)肝转移的治疗方式及研究进展。方法收集GIST肝转移外科治疗的文献并进行综述。结果GIST常发生肝脏转移,严重影响患者的预后。在络氨酸激酶抑制剂(tyrosine kinase inhibitors,TKI)治疗时代,治疗方法首选根治性手术切除联合TKI治疗,此外还可根据患者的病情选择射频消融、介入治疗等辅助方法。结论手术完整切除肿瘤和TKI治疗可改善患者的预后,提高存活率,是GIST肝转移患者的最有效治疗方式。GIST肝转移患者需要多学科及多模式联合治疗。

Treatment for gastrointestinal stromal tumor with liver metastasis

Objective To summarize current treatment methods and research advances of liver metastasis in patients with gastrointestinal stromal tumor(GIST).Method The related literatures about treatment of liver metastasis in patients with GIST were collected and reviewed.Results GIST often occurred liver metastasis,which seriously affected the prognosis of patients.In the era of tyrosine kinase inhibitors(TKI)treatment,radical resection combined with TKI was the first choice.In addition,radiofrequency ablation and interventional therapy could be selected according to the patient’s condition.Conclusions Complete resection of tumor and TKI treatment can improve the prognosis and survival rate of GIST patients with liver metastasis.GIST patients with liver metastasis need multidisciplinary and multi-mode combined treatment.