| 轻微型肝性脑病患者静息状态下脑缺省模式网络 |
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| 引用本文： | 戚荣丰,张龙江,张志强,钟元,张宗军,卢光明. 轻微型肝性脑病患者静息状态下脑缺省模式网络[J]. 中国医学影像技术, 2010, 26(1): 47-50 |
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| 作者姓名： | 戚荣丰 张龙江 张志强 钟元 张宗军 卢光明 |
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| 作者单位： | 南京大学医学院临床学院,南京军区南京总医院影像科,江苏,南京,210002 |
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| 基金项目： | 国家自然科学基金，江苏省自然科学基金 |
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| 摘 要： | 目的 利用静息功能磁共振成像(fMRI)观察轻微型肝性脑病(MHE)患者脑缺省模式网络的改变. 方法对14例MHE患者和14名正常对照者行静息状态下的功能磁共振扫描,利用独立成分分析方法,分离得到各自的脑缺省模式网络脑区,各组进行单样本t检验组内分析和两样本t检验组间分析,观察MHE患者静息状态下脑缺省模式网络的改变. 结果 MHE患者和正常对照组均显示出典型的静息态脑缺省模式网络空间分布模式.但与正常对照组相比,MHE患者大部分脑缺省模式网络脑区功能连接降低,包括:左侧后扣带回、双侧前扣带回、双侧额中回、左侧海马旁回;而右侧楔前叶的功能连接较正常对照组升高. 结论静息状态下,MHE患者大部分脑缺省模式网络脑区功能连接度下降,而楔前叶增加,反映了MHE患者的大脑内源性功能组织发生损伤.静息fMRI可用于观察MHE患者脑缺省模式网络的改变.
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| 关 键 词： | 肝性脑病 磁共振成像 缺省模式网络 |
| 收稿时间： | 2009-06-25 |
| 修稿时间： | 2009-08-24 |
Default-mode network in patients with minimal hepatic encephalopathy |
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| QI Rong-feng,ZHANG Long-jiang,ZHANG Zhi-qiang,ZHONG Yuan,ZHANG Zong-jun and LU Guang-ming. Default-mode network in patients with minimal hepatic encephalopathy[J]. Chinese Journal of Medical Imaging Technology, 2010, 26(1): 47-50 |
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| Authors: | QI Rong-feng ZHANG Long-jiang ZHANG Zhi-qiang ZHONG Yuan ZHANG Zong-jun LU Guang-ming |
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| Affiliation: | Department of Medical Imaging, Clinical College of Medical School of Nanjing University,Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Clinical College of Medical School of Nanjing University,Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Clinical College of Medical School of Nanjing University,Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Clinical College of Medical School of Nanjing University,Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Clinical College of Medical School of Nanjing University,Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Clinical College of Medical School of Nanjing University,Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China |
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| Abstract: | Objective To investigate the alteration of the default-mode network(DMN)in the patients with minimal hepatic encephalopathy(MHE)using resting functional MRI,and to explore its underlying clinical significance.Methods Fourteen MHE patients and 14 age-matched normal controls underwent standard resting state functional MRI scan.The components representing DMN were picked out after separation of independent component analysis.One and two sample t-tests were used to observe the changes of DMN in the patients in ... |
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| Keywords: | Hepatic encephalopathy Magnetic resonance imaging Default-mode network |
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