| 兔急性心肌梗死再灌注模型建立的研究 |
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| 引用本文： | 张军,齐晓勇,马晓丽,穆丽萍,王永州,费玲,陈树平. 兔急性心肌梗死再灌注模型建立的研究[J]. 中国医药导刊, 2008, 10(7): 1065-1067 |
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| 作者姓名： | 张军 齐晓勇 马晓丽 穆丽萍 王永州 费玲 陈树平 |
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| 作者单位： | 1. 河北省沧州市中心医院心脏内科,沧州,061001
2. 河北省人民医院心脏中心,石家庄,050071 |
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| 基金项目： | 河北省科学技术研究与发展计划 |
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| 摘 要： | 目的：探讨采用阻断及松解冠状动脉左回旋支之左室支的方法建立兔急性心肌梗死（AMI）再灌注模型方法的可行性及先进性。方法：日本大白兔24只为实验对象，随机分为缺血再灌注组、缺血未灌注组及假手术组，每组8只。阻断左室支血流5min后松开10min，再次阻断5min松开10min,再次阻断60min，然后缺血再灌注组松解进行再灌注，缺血未灌注组在穿线处结扎，假手术组只穿线不阻断血流。采兔术前、再灌注后各时段静脉血，检测cTnI,CK和CK-MB；行心电图观察II,III,avF导联ST段抬高振幅总和变化。结果：各组动物冠脉闭塞前、后体表心电图及冠脉阻断后II,III,avF导联ST段均抬高，缺血再灌注组松解后120分钟内ST段回落大于50%，而其它两组无此表现。结论：应用本研究制模方法可成功建立兔AMI再灌注模型，成功率高。
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| 关 键 词： | 急性心肌梗死 再灌注 模型 |
Establishment of the Reperfusion Model on AMI Rabbits |
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| Zhang Jun,Qi Xiao-yong,Ma Xiao-li,et al.. Establishment of the Reperfusion Model on AMI Rabbits[J]. Chinese Journal of Medicinal Guide, 2008, 10(7): 1065-1067 |
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| Authors: | Zhang Jun Qi Xiao-yong Ma Xiao-li et al. |
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| Affiliation: | Zhang Jun~1,Qi Xiao-yong~2,Ma Xiao-li~1,et al. (~1 Department of Cardiology,Cangzhou Central Hospital,The Affiliated Hospital of Hebei Medical University,Cangzhou 061001,China,~2 Cardiac Center,Hebei Provincial People's Hospital,Shijiazhuang 050051,China) |
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| Abstract: | Objective:To explore the feasibility and procession of the method of establishing the reperfusion model on Acute Myocardial Infarction(AMI) rabbits.Method:A total of 24 healthy Japanese albino rabbits of both sex were used in this study.Rabbits were randomly divided into 3 groups:ischemia-reperfusion group(IR group,8 ),ischemia-noperfusion group(AMI group,8 ),sham group(sham, 8).After preconditioning the myocardium twice by obstructing the blood flow for 5 minutes,we obstructed the flow of Left Anterior Ven... |
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| Keywords: | Acute Myocardial Infarction reperfusion model |
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