抗胆碱能药在休克治疗中的炎性抑制作用

脓毒性休克和创伤失血性休克均可能发展为全身性炎性反应综合征,甚至多器官功能障碍综合征,导致预后不良和死亡。近年来,抗胆碱能药防治休克-复苏后肺部炎性反应的作用机制研究较为活跃,主要集中在对炎性细胞和炎性介质的干预上。长托宁(盐酸戊乙奎醚)是一种新型的抗胆碱能药物,与阿托品和山莨菪碱相比有更多的优点而受到重视,但有关用药的剂量与时间,尚需进一步研究。

Anti-inflammation Effect of Anticholinergic Drugs in Shock Treatment

Both septic shock and trauma-hemorrhagic shock can develope into systemic inflammatory reaction syndrome,even multiple organ dysfunction syndrome,which would result in bad prognosis and death.In recent years,much work has paid close attention to the mechanism of inflammatory reaction in lung after shock and resuscitation,especially in intervention of inflammatory cells and mediators,As a new type anticholinergic drug,penehyclidine hydrochloride has more good advantages than atropine,anisodamine and others.H...