胃癌术中腹腔内温热灌注化疗的临床应用

目的 探讨中晚期胃癌行根治或姑息切除联合术中腹腔内温热灌注（IPHP）化疗的无期疗效。方法 1987年10月－1997年10月间收治的中晚期胃癌71例，其中IPHP组37例，对照组34例。IPHP组在手术关腹前，使用加温灌注装置将加温的氟尿嘧啶溶液连续灌注入腹腔，腹腔内液本的温度维持在42℃－43℃之间，时间60min。结果 IPHP化疗后12例腹腔内广泛转移、腹腔种植伴腹水的患者，腹水很快消失。经治疗患者全部出院，追踪随访年生存率（51．6％）较对照组（32．3％）明显提高（P＜0．05）。结论 术中IPHP化疗临床应用安全可行。

Clinical application ofIPHP chemotherapy for gastric cancer

Objective　To evalute long-term effect of combined therapy (radical or palliative resection of carcer and intraperitoneal hyperthermic perfusion (IPHP) chemotherapy) for advenced garstric cancer (GC) from October 1987 to October 1997 in our haspital. The cases were randomly divided into two groups: IPHP group (37 cases) and control group (34 cases). In IPHP group, before suture the abdomine, heated 5-Fu solution in abdominal cavity should be maintained at 42～43℃ for 60 minutes. Results　After IPHP chemotherapy, 12 patients with cancer cells widespreading in abdominal carity, refractable ascites were disappeared. All the patients were dischargd after IPHP. The 5-year survival rate in IPHP group (51.6%) was significanfly highter than that in control group (32.3%) (P<0.05).