Microsatellite instability in adult T-cell leukaemia |
| |
| Authors: | Yoshihiro Hatta,Yasuaki Yamada,Masao Tomonaga,Isao Miyoshi,Jonathan W. Said,& H. Phillip Koeffler |
| |
| Affiliation: | Division of Hematology/Oncoclogy, Cedars-Sinai Research Insitute, UCLA School of Medicine, Los Angeles, California, U.S.A.,;Departments of Laboratory Medicine and Haematology, Nagasaki University School of Medicine, Nagasaki, Japan,;Department of Internal Medicine, Kochi Medical School, Kochi, Japan,;Department of Pathology, Center for the Health Sciences, UCLA School of Medicine, Los Angeles, California, U.S.A. |
| |
| Abstract: | Microsatellite instability (MSI) is thought to represent a defect of the DNA mismatch repair system which has been implicated in the tumourigenesis of several human malignancies. We investigated MSI in acute/ lymphomatous adult T-cell leukaemia (ATL; n =22) using 54 highly polymorphic dinucleotide short-tandem repeat sequences. The corresponding control DNA from each individual was obtained from the peripheral blood in either chronic phase ( n =5) or when complete remission was achieved ( n =17). 10/22 (41%) patients had MSI, six of whom showed MSI in multiple loci; four loci had MSI in multiple samples. The incidence of MSI in ATL was found to be higher than in other haematological malignancies, indicating MSI as a feature of ATL, which may be involved in the progression of the disease. |
| |
| Keywords: | adult T-cell leukaemia mismatch repair microsatellite instability leukaemogenesis replication error |
|
|
