依达拉奉在急性脑梗死时抗氧化及神经内皮保护作用的研究

目的研究依达拉奉对急性脑梗死患者血清超氧化物歧化酶（SOD）、丙二醛（MDA）表达的影响。并分析其临床意义。方法选择急性脑梗死患者120例随机分为对照组（常规治疗）和依达拉奉组（依达拉奉＋常规治疗,依达拉奉30mg＋0．9％氯化钠溶液100ml,静脉滴注,2次／d,连续14d）,每组60例,检测治疗前、发病72h和治疗后7、14d患者血清中SOD、MDA的变化。结果依达拉奉组治疗后血清SOD升高、MDA减少,发病72h和治疗后7d与对照组比较差异有统计学意义（P〈0．05）。结论急性脑梗死患者应用依达拉奉治疗可以降低氧自由基水平,减轻对缺血脑细胞的损害。

Antioxygen and neuroprotective effect of edaravone on patients with acute cerebral infarction

Objective To investigate the influence of edaravone on serum superoxide dismutase （SOD） and malondialdehyde （MDA） levels in acute cerebral infarction patients and to analyze its clinical significanae. Methods 120 patients with acute cerebral infarction were randomly divided into control group （ n = 60 ）and edaravone group（ n = 60）, the patients in control group were given routine treatment, while the patients in edaravone group, apart from routine tharapy,were added edaravone 30 mg, twice a day, with a treatment course of 14 day for both groups;the serum levers of SOD and MDA were detected before treatment, invasion 72 hours and 7d, 14d after treatment. Results The serum levels of SOD in edaravone group is significantly higher, however, the serum levels of MDA is significantly lower than those of control group（ P 〈 0.05 ） in invasion 72 hour and 7d after treatment. Conclusion Edaravone can reduce free radical and the injury of ischemic brain cells and can improve therapeutic effect.