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| 都梁丸提取液镇痛作用及对外周组织c-fos基因表达影响的实验研究 | |
| 引用本文： | 韩笑,刘文,邱德文,许建阳. 都梁丸提取液镇痛作用及对外周组织c-fos基因表达影响的实验研究[J]. 中国实验方剂学杂志, 2003, 9(4): 34-36 |
| 作者姓名： | 韩笑 刘文 邱德文 许建阳 |
| 作者单位： | 1. 中国中医研究院西苑医院实验研究中心,北京,100091 2. 贵阳中医学院,贵州,贵阳,550002 3. 武警总医院,北京,100039 |
| 摘 要： | 目的 :研究都梁丸提取液对炎性疼痛动物模型的镇痛作用及其对外周组织c fos基因表达的影响 ,为其镇痛作用机理提供依据。方法 :测定完全福氏佐剂 (FCA)所致大鼠疼痛模型的痛阈值 ,免疫组织化学法检测外周组织c fos的表达情况。结果 :都梁丸提取液能提高炎性疼痛模型痛阈值 ,抑制外周组织c fos的表达 ,与模型组相比具显著性差异 (P <0 0 5 )。结论 :都梁丸提取液具镇痛作用 ,其作用可能与抑制外周组织c fos基因的表达有关。 |
| 关 键 词： | 都梁丸 镇痛 c－fos基因 |
| 文章编号： | 1005-9903(2003)04-0034-03 |
| 收稿时间： | 2002-10-08 |
| 修稿时间： | 2002-10-08 |
Study on Analgesic Effect of Duliang Pill(DLP) Extract and Its Effect on C-fos Gene Expression of Periphery Tissue |
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| HAN Xiao,LIU Wen,QIU De-wen,XU Jian-yang. Study on Analgesic Effect of Duliang Pill(DLP) Extract and Its Effect on C-fos Gene Expression of Periphery Tissue[J]. China Journal of Experimental Traditional Medical Formulae, 2003, 9(4): 34-36 | |
| Authors: | HAN Xiao LIU Wen QIU De-wen XU Jian-yang |
| Affiliation: | HAN Xiao+1,LIU Wen+2 QIU De wen+2 XU Jian yang+3 |
| Abstract: | Objective:To study the analgesic mechanism of DLP extract on FCA induced pain model. Methods:Experiment detected the pain threshold, pain grade and the expression of c fos gene in periphery tissue by using the methods of immunohistochemistry. Results DLP extract showed obvious effects, compared with model group ( P <0 05), on enhancing the pain threshold and restraining the Fos expression of periphery tissue. Conclusion:DLP extract has analgesic effect and its analgesic effect was probably associated with its effect on restraining the Fos expression of periphery tissue. |
| Keywords: | Duliang Pill Analgesic C fos gene |
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