复方中药康赛德止痛汤对海洛因依赖性恒河猴戒断反应治疗作用的研究

目的:观察复方中药康赛德止痛汤(CDC)对海洛因依赖性戒断反应的治疗作用。方法:本研究采用海洛因造成恒河猴依赖模型,用复方中药康赛德止痛汤(以下简称CDC)与美沙酮进行对比治疗研究,观察评定 CDC 对停用海洛因后猴躯体戒断反应的治疗作用,并将各组戒断反应最重的前4天得分进行比较。结果:CDC 与美沙酮一样,对海洛因依赖猴戒断反应有着相同的治疗作用。CDC 及美沙酮组分别与自然戒断组得分值比较,有显著性差异(P<0.01);而 CDC 组与美沙酮组之间未见显著性差异(P>0.05)。结论:CDC 对猴海洛因依赖性戒断反应有治疗作用。

Study on Therapeutic Effect of Comdrugcide Compound inTreating Withdrawal Syndrome of Heroin-Dependent in Rhesus Monkeys

Objective:To study and assay the therapeutic effect of Comdrugcide compound(CDC)in the treatment for withdraw- al reaction of heroin-dependent in rhesus monkeys after withdrawal of heroin.Methods:Making modds of heroin-depen- dent rhesus monkeys by means of heroin;studying and assaying the therapeutic effect of CDC on the withdrawal reactions of the monkeys after withdrawal of heroin;comparing the scores acquired by different groups.Results:CDC has the same inhibitory action as methadon Statistical data showed that there was significant difference between the score acquired by ei- ther CDC group or methadone control group and the score acquried by the naturally withdrawal group(P<0.01);but there was no significant difference between the score of CDC group and that of methadone control group(P>0.05).Con- clusion:CDC has therapeutic effect on the withdrawal reaction oeeuring in heroine-dependent rhesus monkeys after with- drawal of heroin.