氯沙坦联合依那普利治疗高血压逆转左室肥厚的临床观察

目的 观察氯沙坦联合依那普利治疗高血压逆转左室肥厚的疗效。方法 84例高血压左室肥厚(LVH)随机分为治疗组(45例)和对照组(39例)。治疗组给予氯沙坦联合依那普利治疗，对照组单用依那普利治疗，观察6个月。治疗前后分别测血压、室间隔厚度(LVST)、左室后壁厚度(PWT)、左室舒张束期内径(LVDd)、E、A、E/A计算左室重量指数(LVMI)。结果 两组血压均明显下降，组问比较治疗组LVST、PWT、LVMI、LVDd及E/A优于对照组。结论 氯沙坦联合依那普利在有效降压的同时，能更有效地逆转LVH，改善左室舒张功能。

The clinial observation of Losartan in combination with enalapril in treating hypertension and reversing left ventricular hypertrophy

Objective: To evaluate the clinical therapeautic efficacy of Losartan in combination with Enalapril in treating hypertension and reversing left ventricular hypertrophy (LVH). Methods: Eighty-four hypertension patients with LVH were divided randomly into Losartan in combination with Enalapril treatment group(n=45) and 6 months Enalapril control group (n=39),The clinical efficacy, blood pressure, IVST, PWT, LVMI, LVDd and E, A, E/A were observed before and after the treatment. Results: The blood pressure of the twogroups decreased significantly. LVST, PWT, LVMI, LVDd, E, A and E/A were much improved in the treatment group compared with those in the control group. Conclusion: Losartan in combination with Enalapril can significantly decrease blood pressure and is more effective than Enalapril alone in reversing LVH and improving left ventricular diastolic function.