Hydrogen peroxide upregulates TNF-related apoptosis-inducing ligand (TRAIL) expression in human astroglial cells, and augments apoptosis of T cells |
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Authors: | Kwon Daeho Choi In-Hong |
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Institution: | Department of Microbiology, Ajou University College of Medicine, Seoul, Korea. |
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Abstract: | The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL- mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions. |
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Keywords: | Astroglial cells hydrogen peroxide TRAIL cyclosporin A apoptosis oxidative stress neuroimmunology |
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