| 具有抗过敏活性的7－羟基－2－（1H－四氮唑－5－基）色酮的合成 |
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| 引用本文： | 李国青,李展,卢玉华. 具有抗过敏活性的7－羟基－2－（1H－四氮唑－5－基）色酮的合成[J]. 中国药物化学杂志, 1996, 0(1) |
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| 作者姓名： | 李国青 李展 卢玉华 |
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| 作者单位： | 中国医学科学院药用植物研究所 |
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| 摘 要： | 具有抗过敏活性的７－羟基－２－（１Ｈ－四氮唑－５－基）色酮的合成李国青，李展，卢玉华（中国医学科学院药用植物研究所，北京１０００９４）许多色酮类化合物具有抗过敏活性，如治疗过敏性支气管哮喘等。色甘酸二钠是使用最广泛的平喘药物之一，但其缺点是口服无效［...
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Synthesis of an Antiallergic Compound 7-Hydroxy-2(1H-Tetrazole-5-yl)-4H-1-Benzopyran-4-One |
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| Li Guoqing, Li Zhan, Lu Yuhua. Synthesis of an Antiallergic Compound 7-Hydroxy-2(1H-Tetrazole-5-yl)-4H-1-Benzopyran-4-One[J]. Chinese Journal of Medicinal Chemistry, 1996, 0(1) |
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| Authors: | Li Guoqing Li Zhan Lu Yuhua |
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| Abstract: | Hydroxy-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-4-one(4) possesses antiallergic activity.From resorcinol, methyl 7-hydroxy-4-oxa-4H-1-benzopyran-2-carboxylate(1) was prepared in 60% yield. After amination of(1) with ammonia, the obtained compound(2) was treated with SOCl2 in DMF to produce (3) in 82% yield. (2) was reacted with POCl3 in DMF to produce(3) and other products. Finally, (3) was reacted with NaN3 to yield(4).The total yield of(4) was 36%. |
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| Keywords: | Antiallergic 4H-1-benzopyran-4-one Synthesis |
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