| 白藜芦醇对大鼠创伤性脑水肿的影响及超微结构观察 |
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| 引用本文： | 周杰,章翔,蒋晓帆,高大宽,章薇,梁景文,常洪波. 白藜芦醇对大鼠创伤性脑水肿的影响及超微结构观察[J]. 西北国防医学杂志, 2006, 27(2): 116-118,F0003 |
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| 作者姓名： | 周杰 章翔 蒋晓帆 高大宽 章薇 梁景文 常洪波 |
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| 作者单位： | 第四军医大学西京医院神经外科,陕西,西安,710032 |
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| 摘 要： | 目的：探讨白藜芦醇对自由落体伤大鼠脑水肿的影响及超微结构变化。方法：采用自由落体伤获得大鼠脑创伤模型，白藜芦醇腹腔注射治疗，取创伤区脑组织，烤箱内干燥，根据烘烤前后质量差，得出脑含水量，用统计方法分析数据；另取部分伤区脑组织行电子显微镜观察。结果：白藜芦醇治疗后大鼠脑含水量差异性明显，超微结构亦有不同改变。结论：白藜芦醇能减轻创伤后大鼠脑水肿，同时对伤区脑组织超微结构有保护作用。
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| 关 键 词： | 脑创伤 白藜芦醇 脑水肿 超微结构 |
| 文章编号： | 1007-8622（2006）02-0116-03 |
| 收稿时间： | 2005-12-10 |
| 修稿时间： | 2005-12-10 |
Protective effects of resveratrol on brain edema and ultramicrostructure of rats with brain trauma |
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| ZHOU Jie, ZHANG Xiang, JIANG Xiao-fan. Protective effects of resveratrol on brain edema and ultramicrostructure of rats with brain trauma[J]. Medical Journal of National Defending Forces in Northwest China, 2006, 27(2): 116-118,F0003 |
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| Authors: | ZHOU Jie ZHANG Xiang JIANG Xiao-fan |
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| Abstract: | Objective:To study the effects of resveratrol on brain edema and ultramicrostructure of rats with brain trauma.Methods: Feeney's method was used to establish the brain injury model of rats.We measured the change of water content and observed the ultramicrostructure of brain tissue after the administration of resveratrol(50 mg/kg,ip).Results:After the administration of resveratrol,the water content decreased significantly,the destruction of ultramicrostructure diminished.Conclusion:Resveratrol has neuroprotective effects on the traumatic brain. |
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| Keywords: | Brain trauma Resveratrol Brain edema Ultramicrostructure |
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