重症监护病房医院感染病原菌分布及耐药性分析

目的 探讨重症监护病房医院感染病原菌的种类、感染部位的分布及细菌耐药性分析.方法 采用ATB Expression细菌半自动鉴定仪及其配套的鉴定卡和药敏卡,对重症监护病房送检的各种标本按细菌检验常规程序进行操作.结果 共检出医院感染病原菌153株,前3位感染病原菌分别是鲍氏不动杆菌（32.0%）、假丝酵母菌属（16.3%）、铜绿假单胞菌（15.0%）,病原菌检出率以下呼吸道标本最高占45.8%,鲍氏不动杆菌对常用的8种抗菌药物除亚胺培南耐药率在4.3%较低外,其余的7种抗菌药物耐药率均＞50.0%.结论 重症监护病房医院感染菌以鲍氏不动杆菌为主且已呈现多重耐药性,应引起临床高度重视.

Pathogens of Nosocomial Infection in Intensive Care Units and Related Drug-resistance Analysis

OBJECTIVE To estimate the distribution of pathogens of nosocomial infection in intensive care units, the sites where infections often taken place and the related antibiotic-resistance of bacteria. METHODS Various samples of bacteria from intensive care units have been examined by applying half-automatic analyzer ATB Expression, with bacteria inspecting cards and drug-sensitivity cards, all from Bio-Merieux, France. RESULTS Totally 153 strains of nosocomial pathogens have been found, where Acinebacter baumannii, fungi and Pseudomonasaeruginosa ranked top three, with rates of 32. 0%, 16. 3%, and 15. 0%, respectively. About 45.8% of pathogens were found in samples from the lower respiratory tract. Approximately 4. 3% of A. baumannii showed drug-resistance to imipenem. However, more than 50.0% of A. baumannii presented its strong drug-resistance to rest of eight regular antibiotics. CONCLUSIONS A. baumannii is a dominating pathogen to cause nosocomial infection in intensive care units, and has shown strong multi-drug-resistance, which should in- cur high clinical attention. It comes to be crucial to highlight sanitization and sterilization operation, applying proper antibiotics in order to reduce appearance of bacteria with drug-resistance.