miR-137基因rs1625579多态性与精神分裂症发病风险的Meta分析 |
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引用本文: | 罗旭东,林举达,邹晓波,殷静雯. miR-137基因rs1625579多态性与精神分裂症发病风险的Meta分析[J]. 海南医学, 2016, 0(4): 656-659. DOI: 10.3969/j.issn.1003-6350.2016.04.051 |
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作者姓名: | 罗旭东 林举达 邹晓波 殷静雯 |
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作者单位: | 广东医学院附属医院精神心理科,广东 湛江,524001 |
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基金项目: | 广东省湛江市科技攻关计划项目(2013B01258) |
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摘 要: | 目的 系统评价miR-137 rs1625579位点基因多态性与精神分裂症发病风险的关系.方法 计算机检索PubMed、Embase、Springer Link、Wiley Online Library、HighWire Press、Google Scholar和CNKI数据库以获取2015年8月之前发表的关于miR-137单核苷酸多态位点rs1625579基因多态性与精神分裂症发病的病例对照研究文献,采用Review Manager5.0和Stata12.0统计软件进行统计分析.结果 最终纳入8篇,miR-137基因rs1625579位点多态性与精神分裂症在显性模型(TT+GT vs GG)、隐性模型(TT vs GT+GG)、加性模型(TT vs GG)和等位基因模型(T vs G)分析中差异有统计学意义(P<0.05).合并OR值分别为1.47、1.21、1.53、1.17;P值分别为0.03、0.001、0.02、0.003.结论 miR-137单核苷酸多态性位点rs1625579与精神分裂症的易感性均具显著相关,为miR-137多态性与精神分裂症关联性的研究提供了理论参考.
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关 键 词: | 精神分裂症 miR-137 rs1625579 多态性 Meta分析 |
Correlation between single nucleotide polymorphism rs1625579 in miR-137 gene and schizophrenia: a meta-analysis |
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Abstract: | Objective To assay the association between the single nucleotide polymorphism (rs1625579) in miR-137 gene and schizophrenia. Methods Studies about the effects of rs1625579 in miR-137 gene on the sensitivity in patients with schizophrenia until Aug. 2015 were searched from PubMed, Embase, Springer Link, Wiley Online Li-brary, HighWire Press, Google Scholar, and China National Knowledge Infrastructure (CNKI). Meta-analysis was per-formed by using Review Manager5.0 and Stata12.0. Results A total of 8 studies were included. A significant associa-tion between rs1625579 and schizophrenia was found using dominant [TT+GT vs GG, P=0.03, odds ratio (OR)=1.47], re-cessive (TT vs GT+GG, P=0.001, OR=1.21), additive (TT vs GG, P=0.02, OR=1.53), and allele (T vs G, P=0.003, OR=1.17) models. Conclusion The results of our study provide convincing evidence that rs1625579 is significantly associ-ated with schizophrenia. |
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Keywords: | Schizophrenia miR-137 rs1625579 Polymorphism Meta-analysis |
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