miR-137基因rs1625579多态性与精神分裂症发病风险的Meta分析

目的 系统评价miR-137 rs1625579位点基因多态性与精神分裂症发病风险的关系.方法 计算机检索PubMed、Embase、Springer Link、Wiley Online Library、HighWire Press、Google Scholar和CNKI数据库以获取2015年8月之前发表的关于miR-137单核苷酸多态位点rs1625579基因多态性与精神分裂症发病的病例对照研究文献,采用Review Manager5.0和Stata12.0统计软件进行统计分析.结果 最终纳入8篇,miR-137基因rs1625579位点多态性与精神分裂症在显性模型(TT+GT vs GG)、隐性模型(TT vs GT+GG)、加性模型(TT vs GG)和等位基因模型(T vs G)分析中差异有统计学意义(P<0.05).合并OR值分别为1.47、1.21、1.53、1.17;P值分别为0.03、0.001、0.02、0.003.结论 miR-137单核苷酸多态性位点rs1625579与精神分裂症的易感性均具显著相关,为miR-137多态性与精神分裂症关联性的研究提供了理论参考.

Correlation between single nucleotide polymorphism rs1625579 in miR-137 gene and schizophrenia: a meta-analysis

Objective To assay the association between the single nucleotide polymorphism (rs1625579) in miR-137 gene and schizophrenia. Methods Studies about the effects of rs1625579 in miR-137 gene on the sensitivity in patients with schizophrenia until Aug. 2015 were searched from PubMed, Embase, Springer Link, Wiley Online Li-brary, HighWire Press, Google Scholar, and China National Knowledge Infrastructure (CNKI). Meta-analysis was per-formed by using Review Manager5.0 and Stata12.0. Results A total of 8 studies were included. A significant associa-tion between rs1625579 and schizophrenia was found using dominant TT+GT vs GG, P=0.03, odds ratio (OR)=1.47], re-cessive (TT vs GT+GG, P=0.001, OR=1.21), additive (TT vs GG, P=0.02, OR=1.53), and allele (T vs G, P=0.003, OR=1.17) models. Conclusion The results of our study provide convincing evidence that rs1625579 is significantly associ-ated with schizophrenia.