老年高血压患者血清尿酸水平与颈动脉粥样硬化的相关性

目的：探讨老年高血压患者血清尿酸水平与颈动脉粥样硬化的关系。方法选取2014年1月至2015年5月我院心内科诊治的109例老年高血压患者，根据患者的血尿酸及颈动脉内膜中层厚度(IMT)水平将其分别分为高尿酸组(n=42)与正常尿酸组(n=67)、IMT正常组(n=45)与IMT增厚组(n=64)，比较各组患者的血脂、尿酸、颈动脉IMT等指标，其中血脂、尿酸采用全自动生化分析仪检测，颈动脉IMT采用彩色多普勒超声检查测量。结果本组109例患者中高尿酸血症发生率为38.53%(42例)；高尿酸组患者血甘油三酯(TG)[(2.83±1.24) mmol/L]、总胆固醇(TC)[(5.80±1.31) mmol/L]、低密度脂蛋白(LDL)[(3.97±0.98) mmol/L]及颈动脉IMT水平[(1.08±0.19) mm]均明显高于正常尿酸组[(2.28±1.12) mmol/L、(5.32±1.13) mmol/L、(3.61±0.82) mmol/L、(0.98±0.12) mm]，差异均有统计学意义(P<0.05)；IMT增厚组患者血尿酸水平为(419.28±60.17)μmol/L，高尿酸血症发生率为51.11%(23/45)，分别高于IMT正常组的(345.92±52.09)μmol/L及29.69%(19/64)，差异均有统计学意义(P<0.05)；相关性分析显示，老年高血压患者血尿酸水平与颈动脉IMT呈正相关(r=0.732，P<0.05)。结论老年高血压患者血尿酸水平与颈动脉IMT呈正相关，可作为反映颈动脉粥样硬化的可靠指标。

Correlation of serum uric acid with carotid atherosclerosis in elderly patients with hypertension

Objective To investigate the relationship between serum uric acid (UA) and carotid atherosclerosis in elderly patients with hypertension. Methods A total of 109 elderly patients with hypertension in our hospital from Jan. 2014 to May 2015 were divided into high UA group (n=42) and normal UA group (n=67) according to the level of UA, as well as normal carotid artery intima-media thickness (IMT) group (n=45) and IMT thickening group (n=64) ac-cording IMT. The lipid, uric acid, carotid IMT were compared, the blood lipids and uric acid were detected by automatic biochemistry analyzer, and carotid artery IMT were measured by color Doppler ultrasound. Results The incidence of hy-peruricemia in the 109 patients was 38.53% (42 patients). The levels of serum triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL) and carotid artery IMT in the high UA group were significantly higher than those in the normal UA group [(2.83±1.24) mmol/L vs (2.28±1.12) mmol/L, (5.80±1.31) mmol/L vs (5.32±1.13) mmol/L, (3.97±0.98) mmol/L vs (3.61±0.82) mmol/L, (1.08±0.19) mm vs (0.98±0.12) mm, P<0.05]. The serum UA level and incidence of hyperurice-mia in IMT thickening group were (419.28 ± 60.17) μmol/L and 51.11% (23/45) respectively, which were significantly higher than those in the normal IMT group of (345.92±52.09)μmol/L and 29.69%(19/64), P<0.05. Correlation analysis showed that uric acid was positively correlated with carotid IMT in elderly patients with hypertension (r=0.732, P<0.05). Conclusion Uric acid is positively correlated with carotid IMT in elderly patients with hypertension, and it can serve as a reliable indicator for carotid atherosclerosis.