| 银翘解毒软胶囊制备过程中绿原酸转移率 |
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| 引用本文： | 刘德军,张源源,张爱丽,苟琼心. 银翘解毒软胶囊制备过程中绿原酸转移率[J]. 中国实验方剂学杂志, 2011, 17(21): 23-26 |
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| 作者姓名： | 刘德军 张源源 张爱丽 苟琼心 |
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| 作者单位： | 江苏联合职业技术学院连云港中医药分院,江苏连云港,222006 |
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| 摘 要： | 目的:研究银翘解毒软胶囊制备过程中各环节绿原酸的转移率,为制备工艺优化及质量控制标准修订提供依据。方法:按《中国药典》所载银翘解毒软胶囊的处方与工艺,用HPLC测定制备过程各环节绿原酸的转移率及相对于上一步的保留率,并测定3个批号银翘解毒软胶囊中绿原酸的含量。结果:3批金银花投料后,乙醇回流提取、减压浓缩、与其他饮片稠膏合并干燥、与挥发油及大豆油制成软胶囊内容物4个环节绿原酸的平均转移率分别为86.1%,77.5%,73.2%,72.8%;相对于上一步的平均保留率分别为86.1%,90.0%,94.6%,99.3%。3批银翘解毒软胶囊每粒平均含绿原酸分别为3.77,3.38,3.86mg。结论:该研究可为银翘解毒软胶囊的生产过程控制和含量限量标准制定提供依据。
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| 关 键 词： | 银翘解毒软胶囊 金银花 绿原酸 转移率 保留率 |
| 收稿时间： | 2011-06-14 |
Transfer Rate of Chlorgenic Acid in Preparation Process of Yinqiao Jiedu Soft Capsules |
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| LIU De-jun,ZHANG Yuan-yuan,ZHANG Ai-li and GOU Qiong-xin. Transfer Rate of Chlorgenic Acid in Preparation Process of Yinqiao Jiedu Soft Capsules[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(21): 23-26 |
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| Authors: | LIU De-jun ZHANG Yuan-yuan ZHANG Ai-li GOU Qiong-xin |
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| Affiliation: | Lianyungang Traditional Chinese Medicine Branch of Jiangsu Union Technical Institute, Lianyungang 222006, China;Lianyungang Traditional Chinese Medicine Branch of Jiangsu Union Technical Institute, Lianyungang 222006, China;Lianyungang Traditional Chinese Medicine Branch of Jiangsu Union Technical Institute, Lianyungang 222006, China;Lianyungang Traditional Chinese Medicine Branch of Jiangsu Union Technical Institute, Lianyungang 222006, China |
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| Abstract: | |
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| Keywords: | Yinqiao Jiedu soft capsules Lonicera japonica chlorgenic acid transfer rate retention rate |
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