两面针分散片的制备及其溶出度

目的:考察两面针分散片最佳处方,确定工艺流程。方法:采用单因素考察和正交试验,以分散均匀性和溶出度为综合指标筛选和优化两面针分散片的最佳处方与工艺。结果:按优化后的处方工艺制备的两面针分散片的崩解时间为20s,分散均匀性好;分散片体外释药参数T50和Td明显小于市售普通片的溶出参数(P<0.01)。结论:所制备两面针分散片具有溶散快,分散均匀,有效成分溶出速率快的特性。

Preparation and Dissolution Study of Dispersible Tablets of Zanthoxylum nitidum

Objective: To examine a suitable formulation for the dispersible tablets of Zanthoxylum nitidum and study the preparation process. Method: The preparative process was scanned out by single factor test and orthogonal design. A comprehensive scoring analysis was performed with disintegrating time and dissolution as the indexes. Result: The optimized dispersible tablets disintegrated in 20 seconds, and the dispersible uniform was excellent. The released rate parameters of dispersible tablets were remarkably smaller than of the control group (P<0.01). Conclusion: Dispersible tablets of Zanthoxylum nitidum had the characteristic of fast and homogeneously dispersing and quick releasing of active constituents.