| 地菍提取物对高血糖模型小鼠血糖的影响 |
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| 引用本文： | 李丽,周芳.地菍提取物对高血糖模型小鼠血糖的影响[J].中国实验方剂学杂志,2011,17(20):187-190. |
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| 作者姓名： | 李丽 周芳 |
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| 作者单位： | 广西中医学院药理教研室,南宁,530001 |
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| 基金项目： | 广西中医药管理局科研课题(gzzc1008) |
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| 摘 要： | 目的:研究地菍提取物对实验性高血糖小鼠血糖的影响。方法:分别以葡萄糖、肾上腺素、链脲佐菌素(STZ)造成小鼠高血糖模型,动物分为空白、模型、阳性药格列苯脲或盐酸二甲双胍、地菍提取物高、中、低(60,40,20 g.kg-1)剂量组,连续ig给药10 d,观察地菍提取物的的降糖作用。同时观察其对正常小鼠血糖的影响。结果:地菍提取物对正常小鼠血糖无影响,对葡萄糖致高血糖小鼠有显著降糖作用(P<0.05,P<0.01),对肾上腺素致小鼠急性高血糖有显著拮抗作用(P<0.01),地菍提取物高、中剂量对STZ致高血糖小鼠有显著降糖作用(P<0.01,P<0.05)。结论:地菍提取物有显著的降血糖作用。
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| 关 键 词： | 地菍 高血糖 血糖 |
| 收稿时间： | 2011/2/21 0:00:00 |
Effect of Aqueous Extract from Melastoma dodecandrum on Blood Glucose in Experimental Hyperglycemic Mice |
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| LI Li and ZHOU Fang.Effect of Aqueous Extract from Melastoma dodecandrum on Blood Glucose in Experimental Hyperglycemic Mice[J].China Journal of Experimental Traditional Medical Formulae,2011,17(20):187-190. |
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| Authors: | LI Li and ZHOU Fang |
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| Institution: | Department of Pharmacology, Guangxi Traditional Chinese Medical University, Mingxiudong Road No.179, Nanning 530001, China;Department of Pharmacology, Guangxi Traditional Chinese Medical University, Mingxiudong Road No.179, Nanning 530001, China |
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| Abstract: | Objective: To study the effect of aqueous extract from Melastoma dodecandrum on blood glucose in experimental hyperglycemic mice.Method: Glucose,adrenaline or streptozotocin was administrated respectively to induce three types of experimental hyperglycemic models in mice.Blood glucose was determined after ten days' administration of the aqueous extract from M.dodecandrum.Result: The aqueous extract from M.dodecandrum.could decrease blood glucose in hyperglycemic mice induced by glucose,adrenaline or strepto... |
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| Keywords: | Melastoma dodecandrum hyperglycemia blood glucose |
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