| 消骨增贴基质配方工艺 |
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| 引用本文： | 闫荟,王苏会,谢予朋,孙世光,杨锋,孙晓迪,史琪荣,张京,刘建华. 消骨增贴基质配方工艺[J]. 中国实验方剂学杂志, 2011, 17(21): 26-29 |
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| 作者姓名： | 闫荟 王苏会 谢予朋 孙世光 杨锋 孙晓迪 史琪荣 张京 刘建华 |
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| 作者单位： | 1. 北京军区总医院药剂科,北京,100700
2. 北京军区总医院保健科,北京,100700 |
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| 摘 要： | 目的:优选消骨增贴基质配方工艺。方法:通过L18(37)正交设计试验,以配方中NP700,甘油,EDTA,PVPPXL-10,甘氨酸铝,PVPK90,药液为因素,其用量为水平,以黏着力、膜残留性、综合指标为考察指标。结果:对黏着力影响最大的是NP700,甘油次之,且他们对黏着力均有显著影响。对膜残留性和综合指标影响最大的是PVPPXL-10。巴布剂基质的最优配方为NP700-甘油-EDTA-PVPPXL-10-甘氨酸铝-PVPK90-药液(6∶30∶0.025∶1∶0.05∶1∶20)。结论:该工艺条件简便易于产业化,按优化后的基质处方制备的凝胶膏剂基质黏性优良,膜残留性低,外观平整光滑,符合药用标准。
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| 关 键 词： | 消骨增贴 凝胶膏剂 基质 正交试验 |
| 收稿时间： | 2011-06-02 |
Matrix Formulation Technology of Xiaoguzeng Patch |
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| YAN Hui,WANG Su-hui,XIE Yu-peng,SUN Shi-guang,YANG Feng,SUN Xiao-di,SHI Qi-rong,ZHANG Jing and LIU Jian-hua. Matrix Formulation Technology of Xiaoguzeng Patch[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(21): 26-29 |
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| Authors: | YAN Hui WANG Su-hui XIE Yu-peng SUN Shi-guang YANG Feng SUN Xiao-di SHI Qi-rong ZHANG Jing LIU Jian-hua |
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| Affiliation: | YAN Hui1,WANG Su-hui1,XIE Yu-peng1,SUN Shi-guang1*,YANG Feng1,SUN Xiao-di1,SHI Qi-rong1,ZHANG Jing1,LIU Jian-hua2(1.Department of Pharmacy,General Hospital of Beijing People's Liberation Army,Beijing 100700,China,2.Department of Health,China) |
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| Abstract: | Objective:To optimize matrix formulation process of Xiaoguzeng patch.Method: L18(37) orthogonal test was designed,NP700,glycerol,EDTA,PVPPXL-10,aluminum glycinate,PVPK90 and liquid medicine as factor,dosage of these as lever.Adhesion force,membrane residues and composite indicator were considered as index.Result: The greatest impact on adhesion force was NP700,followed by glycerol,and they had a significant effect on adhesion force.The greatest impact on membrane residues and composite indicator was PVPPXL-... |
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| Keywords: | Xiaoguzeng patch gel ointment matrix orthogonal test |
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