| 正交试验法优选复方芸归颗粒提取工艺 |
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| 引用本文： | 张霞,王荣,杨建宏,侯延辉. 正交试验法优选复方芸归颗粒提取工艺[J]. 中国实验方剂学杂志, 2011, 17(18): 35-37 |
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| 作者姓名： | 张霞 王荣 杨建宏 侯延辉 |
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| 作者单位： | 1. 宁夏医科大学药学院,银川 750004;宁夏回药现代化工程技术研究中心,银川750004;宁夏医药研究所,银川750004
2. 宁夏医科大学中医学院,银川,750004 |
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| 基金项目： | 宁夏医科大学特殊人才启动项目(XT200807) |
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| 摘 要： | 目的:优选复方芸归颗粒处方药材的提取工艺。方法:以方中君药当归活性成分阿魏酸、枳壳的活性成分柚皮苷提取量为评价指标,高效液相色谱法定量,采用L9(34)正交设计试验法,对复方芸归颗粒制备过程中的水提取工艺进行研究。结果:该颗粒剂水提取最佳工艺条件为加水量分别为12,10倍,浸泡1 h,提取1.5 h。结论:该提取工艺稳定可行,适合于工业化生产,为复方芸归颗粒制剂的研究奠定了基础。
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| 关 键 词： | 复方芸归颗粒 水提取 阿魏酸 柚皮苷 正交试验 高效液相色谱法 |
| 收稿时间： | 2011-05-10 |
Extraction Process of Fufang Yungui Granules by Orthogonal Design |
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| ZHANG Xi,WANG Rong,YANG Jian-hong and HOU Yan-hui. Extraction Process of Fufang Yungui Granules by Orthogonal Design[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(18): 35-37 |
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| Authors: | ZHANG Xi WANG Rong YANG Jian-hong HOU Yan-hui |
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| Affiliation: | College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China; Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine, Yinchuan 750004, China; Ningxia pharmaceutical institute, Yinchuan 750004, China;College of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750004, China;College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China; Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine, Yinchuan 750004, China; Ningxia pharmaceutical institute, Yinchuan 750004, China;College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China; Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine, Yinchuan 750004, China; Ningxia pharmaceutical institute, Yinchuan 750004, China |
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| Abstract: | Objective: To optimize extraction process of crude drug from Fufang Yungui granules. Method: Using extraction rate of ferulaic acid from angelicae sinensis radix and naringin from aurantii fructus as indexes, HPLC was used to quantitative, optimized process of water extraction by L9(34) orthogoral design. Result: The optimum technology of water extraction was as follows: extracted twice with 12 and 10 times the amount of water, soaked 1 h, extracted 1.5 h each time. Conclusion: The optimum extraction technology is stable,feasible and suited for industrialization production.It can settle foundation for preparation of Fufang Yungui granules. |
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| Keywords: | Fufang Yungui granules water extraction ferulaic acid naringin orthogonal design HPLC |
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