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| 剧痛宁贴剂的醇提工艺 | |
| 引用本文： | 徐男,张超,蔡梅超,王淑玲,时海燕.剧痛宁贴剂的醇提工艺[J].中国实验方剂学杂志,2011,17(19):35-37. |
| 作者姓名： | 徐男 张超 蔡梅超 王淑玲 时海燕 |
| 作者单位： | 1. 山东中医药大学药学院,济南,250355 2. 杭州师范大学生物医药与健康研究中心,杭州,310012 3. 北京大学医学部药学院,北京,100191 |
| 摘 要： | 目的:优选剧痛宁贴剂的最佳乙醇提取工艺。方法:以芍药苷、总生物碱和醇浸膏量为指标,采用直接比较法对乙醇提取体积分数进行优选;以芍药苷和醇浸膏量为指标,采用正交试验法对剧痛宁贴剂中白芍、黄连、延胡索的乙醇提取工艺进行优选。结果:将药材中白芍、黄连、延胡索粉碎成粗粉,分别加10,8倍量70%的乙醇提取2次,每次提取2 h。结论:确定的工艺合理,有效成分提取率高。 |
| 关 键 词： | 剧痛宁贴剂 芍药苷 总生物碱 醇浸膏量 正交试验法。 |
| 收稿时间： | 2011/5/10 0:00:00 |
Ethanol Extraction Process of Jutongning Patch |
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| XU Nan,ZHANG Chao,CAI Mei-chao,WANG Shu-ling and SHI Hai-yan.Ethanol Extraction Process of Jutongning Patch[J].China Journal of Experimental Traditional Medical Formulae,2011,17(19):35-37. | |
| Authors: | XU Nan ZHANG Chao CAI Mei-chao WANG Shu-ling and SHI Hai-yan |
| Institution: | College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250014, China;College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250014, China;College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250014, China;Research Center of Biomedicine and Health, Hangzhou Normal University, Hangzhou 310012, China;College of Pharmacy, Medical Department, Peking University, Beijing 100191, China |
| Abstract: | Objective: To optimize ethanol extraction process of Jutongning patch. Method: Optimized concentration of ethanol extract are investigated by direct comparison with paeoniflorin,total alkaloids and the amount of alcohol extracts as index.Optimized ethanol extraction processes of Paeoniae Radix Alba,Coptidis Rhizoma,Corydalis Rhizoma from Jutongning patch are investigated by using orthogonal design.Paeoniflorin and the amount of alcohol extracts were used as index in the investigation. Result: Paeoniae Radix Alba,Coptidis Rhizoma,Corydalis Rhizoma were ground to coarse powder and extracted twice in 70% ethanol with 2 h per time,10 times ethanol for the first time and 8 times ethanol for the second time. Conclusion: The optimum process are rational and has high yield of active constituents. |
| Keywords: | Jutongning patch paeoniflorin total alkaloids the amount of alcohol extracts orthogonal test |
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