中药对内皮祖细胞的影响

主要就中药对内皮祖细胞的影响研究进行文献整理和分析。研究表明,内皮祖细胞(endothelial progenitor cells,EPCs)是血管内皮细胞(endothelial cells,ECs)的前体细胞,可参与血管新生和内皮损伤后的修复,在心血管疾病的发生、发展中扮演了重要角色。中医药治疗心血管疾病有着悠久的历史,能够同时作用于疾病发生的不同环节,多途径、多环节、多靶点直接或间接地影响疾病的进程。一些中药能有效调节EPCs的功能,如影响其动员、分化、归巢、黏附等。全文从临床观察、动物实验、细胞培养等3个方面综述了中药对内皮祖细胞的有效影响,同时探讨了中药对内皮祖细胞的作用机制及目前研究存在问题,以期为心血管领域的中药应用和新药研发提供参考。中药调节EPCs的数量和功能在心血管疾病和肿瘤的防治中具有重要作用。中药结合材料学、生物医学等学科,有可能为最终打破重大疾病防治的瓶颈做出贡献。

Treatment of Endothelial Progenitor Cells Used Traditional Chinese Medicine

Treatment of endothelial progenitor cells (EPCs) used traditional Chinese medicine was introduced in this review. EPCs, the precursor cells of endothelial cells (ECs), can participate in angiogenesis and endothelial injury after repair, which plays an important role in the incidence and development of cardiovascular disease. There is a long history for Chinese medicine to treat cardiovascular disease. It plays an important role in the different stages of disease development simultaneously. Some Chinese herbal medicines adjust the EPCs functions effectively, like influencing their mobilization, differentiation, homing, adhesion, etc. This paper reviewed Chinese medicine in the treatment of endothelial progenitor cells, to improve its application in cardiovascular field and new drug development of traditional Chinese medicine. The adjustment of Chinese medicine on EPCs plays a very important role in disease treatment.