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| 小金缓释微丸的制备及其体外释放度考察 | |
| 引用本文： | 刘文勇,李东勲,关志宇,张国松,刘红宁,罗晓健.小金缓释微丸的制备及其体外释放度考察[J].中国实验方剂学杂志,2011,17(18):22-25. |
| 作者姓名： | 刘文勇 李东勲 关志宇 张国松 刘红宁 罗晓健 |
| 作者单位： | 1. 江西中医学院,南昌,330004 2. 江西中医学院,南昌 330004;中药固体制剂制造技术国家工程研究中心,南昌 330006 3. 中药固体制剂制造技术国家工程研究中心,南昌,330006 |
| 基金项目： | 国家重大新药创制(2009zx09310-005) |
| 摘 要： | 目的:制备小金缓释微丸,并以阿魏酸为指标,考察不同包衣条件下小金缓释微丸的体外释放度。方法:采用单因素试验优选包衣工艺。结果:以乙基纤维素为包衣材料,包衣增重10%,致孔剂乳糖的用量为12%,可满足10 h缓释的要求。结论:包衣材料、包衣增重以及致孔剂的用量是影响药物释放的关键因素。 |
| 关 键 词： | 小金缓释微丸 流化床包衣 体外释放度 |
| 收稿时间： | 2011/3/11 0:00:00 |
Preparation and Release Test in vitro of Xiaojin Sustained Release Pellets |
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| LIU Wen-yong,LI Dong-xun,GUAN Zhi-yu,ZHANG Guo-song,LIU Hong-ning and LUO Xiao-jian.Preparation and Release Test in vitro of Xiaojin Sustained Release Pellets[J].China Journal of Experimental Traditional Medical Formulae,2011,17(18):22-25. | |
| Authors: | LIU Wen-yong LI Dong-xun GUAN Zhi-yu ZHANG Guo-song LIU Hong-ning and LUO Xiao-jian |
| Institution: | Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006, China |
| Abstract: | Objective: To prepare Xiaojin sustained release pellets and investigate release in vitro of Xiaojin sustained release pellets with different coating conditions by ferulic acid was determined as index. Method: Single factor test was applied to optimize the coating formulations. Result: A 10 h-sustained release curve was satisfactorily obtained by using EC as coating material and lactose 12% as porogenic agent in the optimized coating formulation with a 10% of coating weight gained. Conclusion: Coating material,coating weight gained and the amount of porogenic agent are the key factors that can significantly affect the drug release in vitro . |
| Keywords: | Xiaojin sustained release pellets fluidized bed coating release in vitro |
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