|
|||||
|
|
| 中药经鼻腔给药研究 | |
| 引用本文： | 邬伟魁,张海燕,宋伟,贺娅,李芳,郑琴,杨明.中药经鼻腔给药研究[J].中国实验方剂学杂志,2011,17(20):288-293. |
| 作者姓名： | 邬伟魁 张海燕 宋伟 贺娅 李芳 郑琴 杨明 |
| 作者单位： | 1. 江西中医学院现代中药制剂教育部重点实验室,南昌,330004 2. 江西中医学院现代中药制剂教育部重点实验室,南昌 330004;西南交通大学材料先进技术教育部重点实验室,成都610003 3. 江西中医学院现代中药制剂教育部重点实验室,南昌 330004;成都中医药大学,成都611137 |
| 基金项目： | 中医药行业科研专项项目(200708006);"十一五"重大新药创制项目(2009ZX09310-005;2009ZX09103-393) |
| 摘 要： | 主要对中药经鼻腔给药研究进行文献整理和分析。研究表明,中药经鼻腔给药可以在鼻腔起局部治疗作用,或经鼻吸收后向脑内递药发挥中枢治疗作用,还可以起到治疗全身性疾病的作用。综述了近年来中药经鼻腔给药的实验研究及临床运用,主要包括鼻用制剂国内现状、中药经鼻腔给药基础实验研究(给药途径的选择、剂型的选择、辅料的选择、体外释药评价、药代动力学研究、药效学研究、脑靶向性、安全评价)、中药鼻用制剂的临床观察实例研究,并对其进行了展望,以期为中药经鼻腔给药临床疾病治疗应用和中药鼻用制剂新药开发提供参考。 |
| 关 键 词： | 经鼻给药 鼻用制剂 吸收促进剂 靶向性 |
| 收稿时间： | 2011/3/18 0:00:00 |
Study on Intranasal Administration of Traditional Chinese Medicine |
|
| WU Wei-kui,ZHANG Hai-yan,SONG Wei,HE Y,LI Fang,ZHENG Qin and YANG Ming.Study on Intranasal Administration of Traditional Chinese Medicine[J].China Journal of Experimental Traditional Medical Formulae,2011,17(20):288-293. | |
| Authors: | WU Wei-kui ZHANG Hai-yan SONG Wei HE Y LI Fang ZHENG Qin and YANG Ming |
| Institution: | Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China; Key Lab. of Advanced Technology of Materials (Chinese Education Ministry), Southwest Jiaotong University, Chengdu 610003, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China; Chengdu University of TCM, Chengdu 611137, China |
| Abstract: | The field of intranasal administration of traditional Chinese medicine is illustrated in this review article.Intranasal administration of traditional Chinese medicine has a local effect on nasal cavity,or delivered from nose to brain to show a centralnervons treatment as well as works in curing systemic diseases. This paper makes an overview of expenrimental study(the route of administration, dosage form selection, the choice of excipients, evaluation of drug release in vitro, pharmacokinetics, pharmacodynamics, brain targeting, safety evaluation) and clinical applications on intranasal administration of Chinese Medicine in recent years and has a bright future,expecting to provide reference for new drug of intranasal preparation of traditional Chinese medicine. |
| Keywords: | intranasal administration nasal preparation absorption enhancer targeting |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《中国实验方剂学杂志》浏览原始摘要信息 | |
| 点击此处可从《中国实验方剂学杂志》下载免费的PDF全文 | |