| 玉米提取物的抗肿瘤作用研究 |
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| 引用本文： | 刘婷,李春英,梁爱华,易艳,郝然,曹春雨,赵雍,王铮.玉米提取物的抗肿瘤作用研究[J].中国实验方剂学杂志,2011,17(18):210-214. |
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| 作者姓名： | 刘婷 李春英 梁爱华 易艳 郝然 曹春雨 赵雍 王铮 |
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| 作者单位： | 1. 中国中医科学院中药研究所,北京,100700
2. 中国医学科学院肿瘤医院肿瘤研究所,北京,100021 |
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| 基金项目： | 国家科技重大专项(2009ZX09301-005) |
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| 摘 要： | 研究玉米乙醇提取物(YM-J)和玉米多糖(YM-S)的体外和体内抗肿瘤活性.方法 采用MTT法测定YMJ,YM-S对人肿瘤细胞株BGC-823和SMMC-7721的体外抑制作用,计算IC50；分别采用人胃癌BGC803裸鼠移植瘤模型和H22小鼠肝癌移植瘤模型,ig YM-J,YM-S,剂量400,200 mg· kg-1,1次/d(胃癌BGC803连续19d,小鼠肝癌连续10 d,检测其体内抗肿瘤作用.结果 YM-J和YM-S对人胃癌细胞BGC-823细胞有较强的抑制作用,IC50分别为24.16,12.61 μg·mL-1；YM-J和YM-S对人肝癌细胞SMMC-7721的抑制作用较弱,IC50分别为127.42,1352.72 μg·mL-1.在人胃癌BGC803裸鼠移植瘤模型和H22肝癌模型,YM-J均可明显抑制肿瘤生长,抑瘤率最高分别为40.27％和44.69％.YM-S对H22肝癌有一定抑瘤作用,抑瘤率38.89％,但对人胃癌BGC803裸鼠移植瘤的抑瘤率最高为25.96％.结论 玉米乙醇提取物YM-J和玉米多糖YM-S在体外和体内均具有一定的抗肿瘤活性,其中乙醇提取物对肝癌和胃癌的抑制作用较强.
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| 关 键 词： | 玉米乙醇提取物 玉米多糖 抗肿瘤 |
| 收稿时间： | 5/9/2011 12:00:00 AM |
The Experimental Study on Antitumor Effect of Maize Extracts |
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| LIU Ting,LI Chun-ying,LIANG Ai-hu,YI Yan,HAO Ran,CAO Chun-yu,ZHAO Yong and WANG Zheng.The Experimental Study on Antitumor Effect of Maize Extracts[J].China Journal of Experimental Traditional Medical Formulae,2011,17(18):210-214. |
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| Authors: | LIU Ting LI Chun-ying LIANG Ai-hu YI Yan HAO Ran CAO Chun-yu ZHAO Yong and WANG Zheng |
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| Institution: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China |
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| Abstract: | |
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| Keywords: | maize ethanol extract maize polysaccharide antitumor |
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