| 乳腺癌靶向治疗的新策略 |
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| 引用本文： | 黄景彬,钟延强. 乳腺癌靶向治疗的新策略[J]. 药学实践杂志, 2011, 29(5): 324-327 |
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| 作者姓名： | 黄景彬 钟延强 |
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| 作者单位： | 第二军医大学药学院药剂教研室,上海,200433 |
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| 摘 要： | 目前,乳腺癌的常规治疗手段如化疗、放疗等存在严重的全身副作用,为此,开展乳腺癌的靶向治疗研究具有重大意义。本文综述了乳腺癌靶向治疗的3个研究领域:抗体介导的靶向、微载体介导的靶向、乳腺癌干细胞靶向,并阐述这些治疗策略的基本研究思路,分析这些新的治疗策略面临的一些问题,从而提出解决这些问题的相关见解。
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| 关 键 词： | 乳腺癌 乳腺癌干细胞 微载体 靶向治疗 |
| 收稿时间： | 2010-12-30 |
| 修稿时间： | 2011-03-17 |
New treatment strategies for targeted therapy of breast cancer |
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| HUANG Jing-bin and ZHONG Yan-qiang. New treatment strategies for targeted therapy of breast cancer[J]. The Journal of Pharmaceutical Practice, 2011, 29(5): 324-327 |
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| Authors: | HUANG Jing-bin and ZHONG Yan-qiang |
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| Affiliation: | Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Common therapies of breast cancer such as chemotherapy, radiotherapy had severe systemic side effects. To reduce those side effects, developing strategies of targeted therapy was necessary. Three research fields on targeted therapy of breast cancer were reviewed in this paper: antibody based breast cancer therapy, microcarrier mediated breast cancer therapy, breast cancer stem cell targeted therapy. The ideas of the tree strategies had been illustrated and the challenges existing in the strategies also been analyzed. Some opinions had been put forward to solve this challenges. |
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| Keywords: | breast cancer breast cancer stem cell microcarrier targeted therapy |
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