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| 单向灌流法研究叶黄素微囊的大鼠在体肠吸收 | |
| 引用本文： | 鲁萍,王新春,陈文,尹俊涛.单向灌流法研究叶黄素微囊的大鼠在体肠吸收[J].中国实验方剂学杂志,2011,17(18):133-136. |
| 作者姓名： | 鲁萍 王新春 陈文 尹俊涛 |
| 作者单位： | 1. 石河子大学药学院,新疆石河子,832002 2. 石河子大学药学院,新疆石河子832002;石河子大学医学院第一附属医院,新疆石河子832008; 3. 神内食品有限公司,新疆石河子,832000 |
| 基金项目： | 科技人员服务企业行动项目(SQ2009GJG4102765) |
| 摘 要： | 目的:研究叶黄素微囊在大鼠在体肠吸收特性。方法:采用单向灌流模型,紫外分光光度法测定在体肠灌流叶黄素微囊质量浓度的变化,研究不同肠段、不同质量浓度叶黄素微囊的吸收部位和吸收机制。结果:叶黄素微囊在大鼠各肠段的吸收速率常数(Ka)、有效渗透系数(Papp)是回肠>空肠>十二指肠>结肠,且各肠段的Ka,Papp值无显著性差异;灌流液中不同质量浓度叶黄素微囊的Ka,Papp值均无显著性差异。结论:叶黄素微囊在大鼠肠道无特定吸收窗,药物质量浓度对叶黄素微囊的Ka,Papp值无影响,其吸收机制为被动扩散。 |
| 关 键 词： | 叶黄素微囊 在体肠吸收 单向灌流法 |
| 收稿时间： | 2011/5/10 0:00:00 |
Study on Intestinal Absorption of Lutein Microscapsules in Rats by in situ Single Pass Perfusion Method |
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| LU Ping,WANG Xin-chun,CHEN Wen and YIN Jun-tao.Study on Intestinal Absorption of Lutein Microscapsules in Rats by in situ Single Pass Perfusion Method[J].China Journal of Experimental Traditional Medical Formulae,2011,17(18):133-136. | |
| Authors: | LU Ping WANG Xin-chun CHEN Wen and YIN Jun-tao |
| Institution: | Pharmacy of College, Shihezi University, Shihezi 832002 China;Pharmacy of College, Shihezi University, Shihezi 832002 China; The First Affiliated Hospital of Medical College, Shihezi University, Shihezi 832008, China;Pharmacy of College, Shihezi University, Shihezi 832002 China;Shennai Food Co. Ltd., Shihezi 832000, China |
| Abstract: | Objective: To study the in situ intestinal absorption behaviors of lutein microscapsules in rats. Method: In situ the rat single-pass intestinal perfusion model was used and the concentrations of the perfusate were determined by UV to investagate the intestinal absorption site and mechanism. Result: The Ka and Papp of Lutein Microscapsules showed ileum>jejunum>duodenum>colon in four different region of rat intestine. The Ka and Papp between four intestinal segments had no significant influence. The Ka and Papp of different drug concentration had no significant influence. Conclusion: Lutein Microscapsules could be absorbed in whole intestinal segment,drug concentration had no effect to Ka and Papp, its absorbing mechanism may be for passive diffusion. |
| Keywords: | Lutein Microscapsules in situ intestinal absorption single-pass intestinal perfusion |
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