Pemetrexed as a possible cause of severe rhabdomyolysis in the treatment of lung cancer |
| |
Authors: | Huang Ming-Shyan Tsai Jong-Rung Shen Mei-Chiou Chou Shah-Hwa Yang Chih-Jen |
| |
Institution: | Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. |
| |
Abstract: | According to many published clinical trials, both haematological and non-haematological toxicities resulting from pemetrexed were relatively mild and therefore this drug is considered to be well tolerated. We came across a 60 y/o woman patient with stage IV adenocarcinoma, suffered from unexpected life threatening complication, rhabdomyolysis. Severe lower leg weakness and respiratory failure occurred on the day 3 after pemetrexed administration. To the best of our knowledge, this is the first report that addresses severe and life-threatening rhabdomyolysis which occur during chemotherapy for the treatment of lung cancer. We believed pemetrexed is a safe drug but we should pay attention to possible complications related to pemetrexed-based treatment and to also treat the life-threatening disorder of rhabdomyolysis immediately to prevent further damage. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|