| 18F-FDG PET/CT定位诊断异位分泌促肾上腺皮质激素肿瘤的价值 |
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| 引用本文： | 张敏,徐昊平,李彪. 18F-FDG PET/CT定位诊断异位分泌促肾上腺皮质激素肿瘤的价值[J]. 中华核医学杂志, 2010, 30(5): 329-332. DOI: 10.3760/cma.j.issn.0253-9780.2010.05.013 |
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| 作者姓名： | 张敏 徐昊平 李彪 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院核医学科,200025 |
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| 基金项目： | 上海市重点学科建设项目 |
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| 摘 要： | 目的 探讨18 F-脱氧葡萄糖（FDG）PET/CT定位诊断异位分泌促肾上腺皮质激素（ACTH）肿瘤的应用价值.方法 疑诊异位分泌ACTH患者共7例,其中男4例,女3例,年龄27～63岁.7例患者均根据临床症状、生化指标或岩下窦采血结果诊断为异位ACTH综合征,同时进行了头颅MR、胸腹部CT、腹部B超及18F-FDG PET/CT检查,以探查原发病灶,并对发现的病灶进行大小及最大标准摄取值（SUVmax）的测量.结果 7例患者中3例经18F-FDG PET/CT找到原发病灶,病灶大小分别为1.1 cm×1.0 cm、1.5 cm×1.1 cm、1.6 cm×1.5 cm,SUVmax值分别为9.4,6.4和12.0.随后对患者进行了肿瘤切除,病理检查结果分别为胸腺瘤、肺部类癌及纵隔类癌.原发灶检出率为3/7.结论 18F-FDG PET/CT在定位诊断异位分泌ACTH肿瘤中具有一定价值.
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| 关 键 词： | 神经内分泌瘤 促肾上腺皮质激素 体层摄影术,发射型计算机 体层摄影术 X线计算机 脱氧葡萄糖 |
The diagnostic value of 18F-FDG PET/CT in the localization of ectopic adrenocorticotrophic hormone-secreting tumors |
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| ZHANG Min,XU Hao-ping,LI Biao. The diagnostic value of 18F-FDG PET/CT in the localization of ectopic adrenocorticotrophic hormone-secreting tumors[J]. Chinese Journal of Nuclear Medicine, 2010, 30(5): 329-332. DOI: 10.3760/cma.j.issn.0253-9780.2010.05.013 |
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| Authors: | ZHANG Min XU Hao-ping LI Biao |
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| Affiliation: | ZHANG Min(Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China) XU Hao-ping(Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China) LI Biao(Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China) |
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| Abstract: | Objective To investigate the diagnostic value of 18F-fluorodeoxyglucose (FDG) PET/CT in the localization of ectopic adrenocorticotrophic hormone ( ACTH)-secreting tumors. Methods Seven patients with ectopic ACTH syndrome (confirmed by clinical symptom, biochemical data or bilateral simultaneous inferior petrosal sinus sampling) were included, 4 males and 3 females with age ranged 27-63 years old.All patients were examined with head MR, chest and abdomen CT, abdomen ultrasonography, and whole body 18F-FDG PET/CT. Location, size, and the maximum standardized uptake value (SUVmax) of the tumor were measured. Results 18 F-FDG PET/CT detected three ectopic ACTH-secreting tumors with the sizes 1. 1 cm×1.0 cm (SUVmax =9.4), 1.5 cm×1.1cm (SUVmax =6.4), and 1.6 cm ×1.5 cm (SUVmax =12.0). The pathological findings of the three tumors were thymoma, lung carcinoid, and mediastinal carcinoid respectively. Conclusion 18 F-FDG PET/CT may help the localization of ecto pic ACTH-secreting tumors . |
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| Keywords: | Neuroendocrine tumors Adrenocorticotrophic hormone Tomography,emission-computed Tomography,X-ray computed Deoxyglucose |
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