| 静脉与肌肉注入单克隆抗体对乙脑病毒感染小鼠的保护作用 |
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| 引用本文： | 刘利兵 姜绍谆. 静脉与肌肉注入单克隆抗体对乙脑病毒感染小鼠的保护作用[J]. 免疫学杂志, 1990, 6(1): 35-37 |
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| 作者姓名： | 刘利兵 姜绍谆 |
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| 作者单位： | 第四军医大学微生物学教研室，第四军医大学微生物学教研室，第四军医大学微生物学教研室，第四军医大学微生物学教研室，第四军医大学微生物学教研室，第四军医大学微生物学教研室 西安 710038，西安 710038，西安 710038，西安 710038，西安 710038，西安 710038 |
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| 摘 要： | 本文探讨了JEV单抗制剂经静脉和肌肉注射对人工感染JEV小白鼠的保护作用。结果表明,肌肉给药组须在小鼠感染后的24小时内给药,保护率才达100％;到小鼠感染后的96小时给药肌肉组的保护率仅26.7％。而静脉给药组到感染后48小时给药,其保护率仍可达100％;感染后96小时给药的保护率为73.3％。静脉给药组和肌肉给药组的保护率相差显著(P<0.05)。这些结果力McAb用于临床治疗选择适宜的给药途径提供了科学依据。
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| 关 键 词： | 单克隆抗体 乙脑病毒 投药 JEV |
Protection of Monoclonal Antibody in the Japanese Encephalitis Virus Infected Mice |
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| Liu Libing et al. Protection of Monoclonal Antibody in the Japanese Encephalitis Virus Infected Mice[J]. Immunological Journal, 1990, 6(1): 35-37 |
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| Authors: | Liu Libing et al |
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| Affiliation: | Liu Libing et alDepartment of Microbiology,The Furth Military Medical University,Xi'an |
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| Abstract: | The protection of monoclonalantibodies in the Japanese Encephalitis Virus (JEV) infected mice was studied. The results showed that the protective rate of monoc lonal antibody from intramuscular route was 100% within 24 hours after challenged by JEV, but the 100% protective rate was achieved even at 43 hours via intravenous route. The survival rate of monoclonal antibody from intravenouse route was 73.33% at96 hours after challenged by JEV,which was higher than that in intramuscular groups(26.C7%) .It clearly indicated that intrave nous route was more effective than intramuscular route in the treatement of JEV-infec ted mice with the monoclonal antibodies. |
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| Keywords: | Monoclonal Antibody Japanese Encephalitis Virus Administration |
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