| CD_3单克隆抗体激活细胞的体外抗肿瘤作用 |
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| 引用本文： | 谢裕安,梁安民,罗小玲,吴继宁.CD_3单克隆抗体激活细胞的体外抗肿瘤作用[J].肿瘤研究与临床,2000(1). |
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| 作者姓名： | 谢裕安 梁安民 罗小玲 吴继宁 |
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| 作者单位： | 广西医科大学肿瘤医院!广西南宁530021 |
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| 摘 要： | 目的:观察CD3单克隆抗体激活的杀伤细胞(CD3AK)的体外杀伤肿瘤作用。方法:采用MTT法测定不同时期CD3AK细胞的杀伤活性。结果:培养到第4天的CD3AK细胞已有明显的杀伤活性,第10天达高峰;CD3AK对K562、H7402和MNK45肿瘤细胞的杀伤活性显著高于LAK和NK细胞(P<0.05),对Hela-3肿瘤细胞的杀伤活性略低于LAK细胞。结论:CD3AK是一种广谱、高效的肿瘤杀伤细胞,但它对不同种类的肿瘤细胞的杀伤效应又存在着较大的差异。
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| 关 键 词： | 单克隆抗体 CD_3AK 杀伤肿瘤 |
TUMOR-KILL ACTION EX VIVO OF CD_3 MONOCLONAL ANTIBODY ACTIVATED KILLER CELLS |
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| XIE Yu an,LIANG An min,LUO Xiao ling,et al Affiliated Tumor Hospital of Guangxi Medical University.TUMOR-KILL ACTION EX VIVO OF CD_3 MONOCLONAL ANTIBODY ACTIVATED KILLER CELLS[J].Cancer Research and Clinic,2000(1). |
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| Authors: | XIE Yu an LIANG An min LUO Xiao ling Affiliated Tumor Hospital of Guangxi Medical University |
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| Abstract: | Objective:To investigate the tumor kill action ex vivo of CD 3 monoclonal antibody activated killer cells (CD 3AK).Methods:MTT method was used to detect tumor kill activity of CD 3AK during different culture period.Results:CD 3AK of the 4th day had obvious kill activity ,and reached to climax at the 10th day.The kill activity of CD 3AK against tumor cell lines K 562 ,H 74302 ,and MNK 45 were markedly stronger than that of LAK and NK(P<0.05),and a little weaker than that of LAK against tumor cell line Hela 3.Conclusion:CD 3AK is a tumor kill cell with broad spectrum and high effect. But there is great difference for its tumor kill effect beween different tumor cells. |
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| Keywords: | Monoclonal antibody CD 3AK Tumor kill |
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