Cyclooxygenase-2 expression in human soft-tissue sarcomas is related to epithelial differentation |
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| Authors: | Lassus Patrik Ristimäki Ari Huuhtanen Riikka Tukiainen Erkki Asko-Seljavaara Sirpa Andersson Leif C Miettinen Markku Blomqvist Carl Haglund Caj Böhling Tom |
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| Affiliation: | Department of Plastic Surgery, HUSLAB, Helsinki University Central Hospital, Helsinki, Finland. patrik.lassus@hus.fi |
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| Abstract: | BACKGROUND: Cyclooxygenase-2 (Cox-2) is expressed by several types of epithelial malignancies, i.e., carcinomas, and inhibition of Cox-2 may have a therapeutic role in chemoprevention and treatment of cancer. The role of Cox-2 in non-epithelial malignancies, however, is unclear. MATERIALS AND METHODS: We investigated, by immuno- histochemistry, the expression of Cox-2 in 103 human soft-tissue sarcomas. RESULTS: All 10 biphasic synovial sarcomas were positive for Cox-2, but positivity was observable only in the epithelial component of these tumours. Excluding sarcomas with epithelial differentation, uniform staining of the tumour was observed in only 2 samples. In addition, positivity for Cox-2 appeared in tumour cells in only 18 samples around necrotic areas. CONCLUSION: In human soft-tissue sarcomas, Cox-2 expression seems to be associated with epithelial differentation and, in some types of sarcomas, to be expressed in otherwise negative tumours at sites of necrosis. |
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