| 新农药叶枯灵的体外代谢转化研究 |
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| 引用本文： | 高宁,孙棉玲.新农药叶枯灵的体外代谢转化研究[J].中国公共卫生学报,1992,11(6):347-350. |
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| 作者姓名： | 高宁 孙棉玲 |
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| 作者单位： | 第三军医大学，华西医科大学，华西医科大学 重庆630038 |
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| 摘 要： | 本文采用 HPLC、TLC、UV、IR 和 MS 对叶枯灵经体外代谢后所形成的代谢产物进行分离和鉴定。结果表明,叶枯灵经体外代谢后所形成的3种代谢产物分别为肼叉-1,3-二噻茂烷,2-苯甲酰肼叉-1,3-二噻茂烷-S-氧和苯甲酸。叶枯灵经酰胺酶的催化可进行水解作用。叶枯灵还可经肝微粒体混合功能氧化酶的作用进行 S-氧化反应。
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| 关 键 词： | 代谢转化 敌枯唑 |
Study on Metabolism and Biotrans-formation of a New Fungicide Ye-Kuling in Vitro |
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| Authors: | Gao Ning Third Military Medical College |
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| Institution: | Chongqing 630038 |
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| Abstract: | The metabolism and biotransformation of a new fungicide Yekuling was studied in vitro. Three metabolites were isolated and purified by means of HPLC and TLC.They were iden- tified to be 1,3-dithiolan-2-ylidenehydrazine,be- nzoic acid,1.3-dithiolan-s-oxo-2-ylidenehydra- zide and benzoic acid.Yekuling was sulfoxida- ted by rat liver microsomal MFO in the pre- sence of NADPH to produce sulfoxide.Yekuling was also hydrolyzed by amidase to form ben- zoic acid and 1,3-dithiolan-2-ylidenehydrazine, |
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| Keywords: | Yekuling metabolism |
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