| 用合成肽研究对丙型肝炎病毒抗原决定簇的抗体反应 |
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| 引用本文： | 闻玉梅 吴长龙. 用合成肽研究对丙型肝炎病毒抗原决定簇的抗体反应[J]. 上海医学, 1992, 15(6): 311-314 |
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| 作者姓名： | 闻玉梅 吴长龙 |
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| 作者单位： | 上海医科大学微生物学教研室，上海医科大学微生物学教研室，上海医科大学微生物学教研室，上海医科大学微生物学教研室，上海医科大学微生物学教研室，卫生部上海生物制品研究所 |
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| 摘 要： |
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| 关 键 词： | 合成肽 抗体反应 丙肝病毒 |
STUDIES ON ANTIBODY RESPONSE VERSUS HEPATITIS C VIRUS BY SYNTHETIC PEPTIDES |
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| Wen Yu-mei,et al.. STUDIES ON ANTIBODY RESPONSE VERSUS HEPATITIS C VIRUS BY SYNTHETIC PEPTIDES[J]. Shanghai Medical Journal, 1992, 15(6): 311-314 |
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| Authors: | Wen Yu-mei et al. |
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| Affiliation: | Wen Yu-mei,et al. Department of Microbiology,Shanghai Medical University,etc. Shanghai 200032 |
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| Abstract: | Five synthetic peptides (EIA-1, EIA-2, EIA-3, EIA-4 and EIA-5) were synthesized according to sequences selected from the viral capsid protein (C) and nonstructural protein regions. Out of 158 anti-HCV positive sera (screened by Abbott 2nd generation kits), 105 were positive for anti-peptide antibodies; among which, antibodies versus EIA-2 and EIA-5 positive rates were the highest, being 89% and 85% respectively. Ameng 62 anti-HCV negative sera, 12 were positive for anti-peptide antibodies and among them 6 sera showed elevated ALT. It is highly suggestive that these 6 sera were from HCV infected individuals. The principles for selection of peptide sequences for mimicking antigenic epitopes and their prospects for future use are discussed. |
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| Keywords: | Synthetic peptides Antibody response Hepatitis C virus |
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