半夏泻心汤及其类方不同配伍对正常大鼠胃液成分的影响

目的为类方的配伍研究提供可参考的试验设计方法.方法用均匀设计法对半夏泻心汤及其类方进行组方药量变化研究,以胃液分析为药理学指标,对所得的药理实验数据进行逐步回归分析.结果在半夏泻心汤、甘草泻心汤方中,各药味对胃液成分的影响其变化趋势类似,但影响程度不尽相同,生姜泻心汤与其他两方出入较大.不同药味之间存在交互作用.结论本方法对类方配伍研究有一定参考价值.

Influence of Banxiaxiexin Decoction and compatibilities of its analogous decoctions on principles of gastric juice in rats

Objective To develop a reference method of experimental design for the study of the compatibilities of different analogous decoctions. Method Banxiaxiexin Decoction and its analogous decoctions were made up and changed by the homogeneous design. Then the pharmacological data were given an analysis of progressive regression with the analysis of gastric juice as the pharmacological indexes. Result The drugs in Banxiaxiexin Decoction and Gancaoxiexin Decoction had similar effects on gastric principles and similar change trends, but they were different in degrees. There was some discrepancy between Shengjiangxiexin Decoction and above two decoctions and there were interactions among the different drugs in these decoctions. Conclution The method of experimental design is worth a reference to the study of the compatibilities of different analogous decoctions.