Congenital long QT syndrome in newborns] |
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Authors: | G Emeriaud S Douchin P S Jouk P Andrini I Wroblewski C Marey A M Rossignol |
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Institution: | Service de réanimation néonatale et infantile, CHU de Grenoble, BP 217, 38043 Grenoble, France. guilemeriaud@hotmail.com |
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Abstract: | The perinatal manifestations of the long QT syndrome are rare, but early diagnosis and therapy are necessary to prevent sudden death. CASE REPORTS: A long QT syndrome was diagnosed in two neonates who presented with foetal bradycardia. In one case, a mutation in the gene KCNQ1 was identified, and a long QT syndrome was diagnosed in the mother and two brothers of the neonate. On beta-blocker therapy, one infant became free of long QT syndrome related symptoms, but a sudden death of the second infant occurred. CONCLUSION: The long QT syndrome should be considered in the differential diagnosis of foetal bradycardia. Early treatment of the neonate and his family may prevent ventricular arrhythmias and sudden death. |
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