Single-dose and multiple-dose pharmacokinetics of zaltoprofen after oral administration in healthy Chinese volunteers |
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Authors: | Lingjun Li Pengcheng Ma Yuping Cao Lei Tao Yue Tao |
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Affiliation: | Lingjun Li,Pengcheng Ma *,Yuping Cao,Lei Tao,Yue Tao Department of Pharmacology,Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing,Jiangsu 210042,China |
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Abstract: | Zaltoprofen, a propionic acid derivative of non-steroidal anti-inflammatory drugs, has strong inhibitory effects on actue and chronic inflammation. A randomized, dose-escalating study was conducted to evaluate the pharma-cokinetics of single and multiple oral doses of zaltoprofen in 12 healthy Chinese volunteers. Pharmacokinetics was determined from serial blood samples obtained up to 24 h after administration of a single dose of zaltoprofen at 80, 160 or 240 mg and after multiple doses of zaltqorofen at 80... |
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Keywords: | zaltoprofen nonsteroidal anti-inflammatory drug pharmacokinetics |
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