化积止痛巴布剂穴位贴敷配合益气化积方内服对H22荷瘤小鼠的抑瘤作用

目的探究化积止痛巴布剂穴位贴敷配合益气化积方内服对H22荷瘤小鼠的抑瘤作用及其作用机理。方法选合格的SPF级昆明种雌性小鼠50只,分为5组,即空白组、模型组、药物组、穴贴组、药物+穴贴组。接种瘤株,各实验组分别给予相应治疗。14d后,观察不同处理方法对H22荷瘤小鼠瘤质量、抑瘤率的影响。结果药物+穴贴组和药物组的瘤质量与模型组比较差异具有统计学意义(P0.01);药物组、穴贴组、药物+穴贴组的抑瘤率分别为22.4%、11.2%、41.1%。结论化积止痛巴布剂穴位贴敷配合益气化积方内服均能减小瘤质量,对H22荷瘤小鼠肿瘤有明显抑制作用,抗肿瘤的机理可能是多环节的。

Antitumor Effect of External Analgesic Navel Acupoint Sticking Cataplasm and Internal Yiqi-dose on H22 Tumor-bearing Mice

Objective To observe and explore the antitumor effect of collective use of external Analgesic acupoint sticking Cataplasm and internal Yiqi-dose on the H22 tumor-bearing mice, and analyze its underlying mechanism supporting for clinical trial. Methods Fifty healthy SPF level Kunming female mice were evenly randomized into 5 groups： blank group, model group, cataplasm group, dose group, collective use group. After tumor vaccination and 14-day treatment, the tumor quality and inhibition ratio of each group were observed and compared. Results There was significant difference in tumor quality of collective use group and dose group compared with model group （P 〈0.01）. The tumor inhibition ratio of dose group, cataplasm group and collective use group was 22.4%, 11.2% and 41.1% respectively. Conclusion Collective use of external Analgesic acupoint sticking Cataplasm and internal Yiqi-dose can decrease the quality of tumor and inhibit the tumor growth of H22 tumor-bearing mice. Its antitumor mechanism could be in many levels.