| 鼻咽癌P53蛋白和血管内皮生长因子及血管内皮生长因子-C表达的临床意义 |
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| 引用本文： | 成伟,梁中敏.鼻咽癌P53蛋白和血管内皮生长因子及血管内皮生长因子-C表达的临床意义[J].牡丹江医学院学报,2008,29(5). |
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| 作者姓名： | 成伟 梁中敏 |
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| 作者单位： | 南方医科大学附属南海人民医院,广东,佛山,528200 |
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| 摘 要： | 目的：探讨P53蛋白、血管内皮生长因子（vascular endothelial growth facor，VEGF）和VEGF—C在鼻咽癌中的的表达及临床意义。方法：通过免疫组化SP法对64例鼻咽癌标本中P53蛋白、VEGF及VEGF—C进行了检测。结果：鼻咽癌中P53蛋白、VEGF及VEGF-C的阳性表达率分别为65．63％、68．75％和54．69％。P53蛋白表达和VEGF存在相关性（P〈0．05）与VEGF-C无相关性（P〉0．05），而在有淋巴结转移的肿瘤中P53、VEGF及VEGF—C阳性表达率明显高于非转移组（P〈0．05）。结论：VEGF表达可能由P53蛋白调节，P53蛋白与VEGF～C调节可能无关，VEGF及VEGF—C与鼻咽癌转移及预后密切相关，P53蛋白可能参与调节，共同参与颈淋巴结转移的过程。
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| 关 键 词： | 鼻咽癌 P53蛋白 血管内皮生长因子 颈淋巴结转移 |
CLINICAL SIGNIFICANCE OF P53 PROTEIN ,VEGF AND VEGF- C EXPRESSION IN NASOPHARYNGEAL CARCINOMA |
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| Cheng Weiet al.CLINICAL SIGNIFICANCE OF P53 PROTEIN ,VEGF AND VEGF- C EXPRESSION IN NASOPHARYNGEAL CARCINOMA[J].Journal of Mudanjiang Medical College,2008,29(5). |
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| Authors: | Cheng Wei |
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| Institution: | Cheng Weiet al(Department of Otolaryngology,Nanhai Hospital of Southern Medical University Guangdong Foshan 528200) |
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| Abstract: | Objective:To evaluate clinical significance of P53 protein,VEGF and VEGF-C expression in nasopharyngeal carcinoma.Methods:Surgically resected specimens of 64 nasopharyngeal carcinomas were studied by immunohistochemical stainning for P53 protein,VEGF and VEGF-C.Results:Positive expressions of P53 protein,VEGF,VEGF-C were found in 65.63%,68.75% and54.69% of nasopharyngeal carcinoma specimens,respectively.There was a positive correlation between the expression of P53 and VEGF expression(P<0.05).No correlation... |
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| Keywords: | Nasophhhharyngealcarcinoma Protein P53 vascular endothelial growth facor lymph node metastasis |
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