| 齐墩果酸脂质体在大鼠体内药代动力学的研究 |
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| 引用本文： | 陈洪轩,牛江秀,肖衍宇,陈志鹏,和平,游国叶. 齐墩果酸脂质体在大鼠体内药代动力学的研究[J]. 中成药, 2010, 32(4): 569-572 |
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| 作者姓名： | 陈洪轩 牛江秀 肖衍宇 陈志鹏 和平 游国叶 |
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| 作者单位： | 河南大学药物研究所;中国药科大学药学院;南京中医药大学药学院; |
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| 摘 要： | 目的:制备齐墩果酸脂质体,研究齐墩果酸脂质体在大鼠体内的药代动力学。方法:采用乙醇注入-探头超声法制备齐墩果酸脂质体;大鼠分别尾静脉注射齐墩果酸脂质体和齐墩果酸溶液剂,用反相高效液相色谱法测定不同时间血浆中齐墩果酸的浓度,采用3p97程序计算药代动力学参数,并进行统计学分析。结果:制得的脂质体透射电镜下为圆形或类圆形的小囊泡,平均粒径为(206.4±4.7)nm,包封率为(97.74±1.34)%;齐墩果酸脂质体和自制的溶液剂经大鼠尾静脉注射后,t1/2α分别为(4.22±1.86)和(0.80±0.34)min;t1/2β分别为(33.59±12.53)和(15.65±7.91)min;AUC分别为(240.13±23.62)和(168.31±18.47)μg/(mL.min),两种制剂的t1/2β和AUC0-t经方差分析后均存在显著性差异(P0.05),齐墩果酸脂质体显著增加了齐墩果酸的AUC,延长了其在血液循环中的时间。结论:制备的齐墩果酸脂质体包封率较高,粒度均匀;与非脂质体相比,齐墩果酸脂质体静脉注射给药后,药代动力学参数发生了明显的改变。
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| 关 键 词： | 齐墩果酸 脂质体 药代动力学 大鼠 |
Pharmacokinetics of oleanolic acid liposomes in rats |
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| CHEN Hong-xuan,NIU Jiang-xiu,XIAO Yan-yu,CHEN Zhi-peng,HE Ping,YOU Guo-ye. Pharmacokinetics of oleanolic acid liposomes in rats[J]. Chinese Traditional Patent Medicine, 2010, 32(4): 569-572 |
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| Authors: | CHEN Hong-xuan NIU Jiang-xiu XIAO Yan-yu CHEN Zhi-peng HE Ping YOU Guo-ye |
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| Affiliation: | CHEN Hong-xuan1,NIU Jiang-xiu1,XIAO Yan-yu2,CHEN Zhi-peng3,HE Ping1,YOU Guo-ye1(1.Institute of Chinese Materia Medica of Henan University,Kaifeng 475004,Henan,China,2.China Pharmaceutical University,Nanjing 210009,Jiangsu,3.Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China) |
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| Abstract: | AIM: To study the pharmacokinetics of oleanolic acid liposomes in rats.METHODS: Oleanolic acid liposomes were prepared by ethanol injection-sonication;The pharmaceutical properties including morphology,encapsulation efficiency,particle size,zeta potential were determined.Rats were injected with oleanolic acid lipo-somes and oleanolic acid solution via the tail,respectively.The plasma concentrations of sample in rats were assayed by RP-HPLC.The pharmacokinetic parameters were computered by 3P97 program packa... |
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| Keywords: | oleanolic acid liposomes pharmacokinetics rat |
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