中山市孕妇血清氨基末端脑钠肽前体水平的监测价值

目的对中山市孕妇血清氨基末端脑钠肽前体（NT-proBNP）水平进行监测,并探讨其与妊娠并发症的关系。方法采用荧光酶免疫法检测2010年中山市博爱医院收治的孕妇血清NT-proBNP水平。结果荧光酶免疫法检测的1 393例正常孕妇的血清NT-proBNP平均水平为（63.31±49.32）pg/ml,与2008年6月-2009年12月用电化学发光免疫分析测定1 860名正常孕妇的NT-proBNP水平（56.93±42.04）pg/ml]相比,两者间差异有统计学意义（t=3.26,P=0.001）。正常孕妇的年龄对NT-proBNP无影响（F=1.632,P=0.3180）,且NT-proBNP值与孕周无关（F=0.405,P=0.876）。与正常组孕妇相比,合并有死胎、妊高征、心功能不全和贫血的孕妇的NT-proBNP值均显著升高（F=41.770,P=0.000）。随着妊高征的严重程度分级增高,NT-proBNP值逐渐升高（F=3.538,P=0.032）,与轻度妊高征相比,重度妊高征差异有统计学意义。结论通过检测孕妇血清NT-proBNP水平,可尽早发现孕妇的并发症,特别是在妊高征监测中具有较大意义。

Value of Monitoring the Serum Level of NT- proBNP Among Pregnant Women in Zhongshan

Objective To monitor the serum level of NT-proBNP in pregnant women in Zhongshan,and to explore its relationship with pregnancy complications.Methods Fluorescent enzyme immunoassay was used to detect the serum level of NT-proBNP in pregnant women from Zhongshan Boai Hospital in 2010.Results The average serum level of NT-proBNP was(63.31±49.32) pg/ml in 1,393 cases of normal pregnant women measured by fluorescent enzyme immunoassay in 2010,and that of 1,860 cases was(56.93±42.04) pg/ml by electrochemical luminescence immunoassay from June 2008 to December 2009,and a statistically significant difference was found between them(t=3.26,P=0.001).Our data showed that the age of normal pregnant women had no effect on the NT-proBNP level(F=1.632,P=0.3180),and there was no relationship between NT-proBNP and the gestational age(F=0.405,P=0.876).Compared with the control group,the levels of NT-proBNP were significantly increased(F=41.770,P=0.000) in pregnant women with stillbirth,pregnancy-induced hypertension syndrome(PIH),cardiac insufficiency and anemia.With higher classification of PIH,NT-proBNP levels increased gradually(F=3.538,P=0.032),there were statistically significant differences between severe PIH and mild PIH.Conclusions It may be beneficial to early detection of the complications of pregnancy by determining the level of serum NT-proBNP.Especially,it has greater significance in the PIH monitoring.