| DNA甲基化在胃癌发生中的作用 |
| |
| 引用本文： | 程翌,郑国荣.DNA甲基化在胃癌发生中的作用[J].实用预防医学,2011,18(6):1164-1166. |
| |
| 作者姓名： | 程翌 郑国荣 |
| |
| 作者单位： | 广州军区武汉总医院消化内科,湖北武汉,430070 |
| |
| 摘 要： | DNA甲基化是重要的表观遗传修饰之一,它在基因表达调控过程中起着重要作用。DNA甲基化异常与肿瘤发生关系密切。启动子区域CpG岛高甲基化导致抑癌基因表达失活是目前肿瘤研究中的热点课题。本文就DNA甲基化在胃癌发生中的作用予以综述,旨在为揭示胃癌发生机制、寻找胃癌早期诊断的分子标志物及干预治疗的靶点提供新的思路。
|
| 关 键 词： | 胃癌 表观遗传学 DNA甲基化 |
Role of DNA Methylation in Genesis of Gastric Cancer |
| |
| CHENG Yi,ZHENG Guo-rong.Role of DNA Methylation in Genesis of Gastric Cancer[J].Practical Preventive Medicine,2011,18(6):1164-1166. |
| |
| Authors: | CHENG Yi ZHENG Guo-rong |
| |
| Institution: | (Department of Gastroenterology,Wuhan General Hospital of Guangzhou Command,Wuhan 430070,Hubei,China) |
| |
| Abstract: | DNA methylation is one of the major ways of epigenetic modulation and it plays a critical role in the regulation of gene expression.During the development and progression of gastric cancer,many genes are silenced by aberrant methylation of CpG islands.Studies for the relationship between DNA methylation and gastric cancer may demonstrate the genesis of gastric cancer,and look for the molecular marker for the diagnosis of gastric cancer and the target of gene therapy. |
| |
| Keywords: | Gastric cancer Epigenetics DNA methylation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
