| 烟碱预处理对全身炎症反应综合征大鼠血浆细胞因子的影响研究 |
| |
| 引用本文： | 凌丽,肖雪,刘安平,谢雪莲.烟碱预处理对全身炎症反应综合征大鼠血浆细胞因子的影响研究[J].实用心脑肺血管病杂志,2011,19(11):1871-1874. |
| |
| 作者姓名： | 凌丽 肖雪 刘安平 谢雪莲 |
| |
| 作者单位： | 遵义医学院附属医院急诊科,贵州省遵义市,563003 |
| |
| 摘 要： | 目的通过复制＂两次打击＂SIRS大鼠模型,探讨迷走神经切断及烟碱预处理对大鼠SIRS的作用,为临床治疗SIRS提供新思路。方法选择雄性健康SD大鼠40只,随机将40只实验动物分为4组,每组10只,对照组未予处理;单侧迷走神经切断组：在诱导SIRS模型前7d,行右侧颈部迷走神经切断;烟碱预处理组：在诱导SIRS模型前7d,开始每天给予烟碱液5mg.kg-1ip;联合迷走神经切断＋烟碱预处理组：在诱导SIRS模型前7d,联合迷走神经切断＋烟碱预处理。造模前晚禁食,不禁水,术日采用戊巴比妥钠腹腔注射麻醉,无菌条件采用腹颈正中切口显露右侧颈部迷走神经主干。比较4组大鼠TNF-a、IL-6含量。结果迷走神经切断后能提高炎症反应,烟碱预处理后能降低炎症反应,联合二者处理后炎症反应介于两者之间,且与未行迷走神经切断和烟碱预处理时炎症反应应答能力亦存在差别。结论中枢神经能够通过副交感神经途径调节炎症反应;烟碱具有较强的抗炎作用,其可不依赖于迷走神经的完整性而独立发挥作用。
|
| 关 键 词： | 两次打击 迷走神经切断 烟碱预处理 全身炎症反应综合征 |
Nicotine Pretreatment on SIRS Rats Effect of Plasma Cell Factors |
| |
| LING Li,XIAO Xue,LIU An-ping,et al..Nicotine Pretreatment on SIRS Rats Effect of Plasma Cell Factors[J].Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease,2011,19(11):1871-1874. |
| |
| Authors: | LING Li XIAO Xue LIU An-ping |
| |
| Institution: | LING Li,XIAO Xue,LIU An-ping,et al.Affiliated Hospital of Zunyi Medical College,Zunyi 563003,China |
| |
| Abstract: | Objective By copying the two-hit SIRS rats model of vagotomy and nicotine pretreatment on the mechanism of SIRS provide new ideas for the treatment or more effective treatment approach for clinical.Methods 40 male SD rats were randomly divided into A,B,C,D four groups,n = 10,A group(Control group) induced SIRS model in the first 7 days,not treated;B group(Unilateral vagotomy group):induction of SIRS model in the first 7 days of right vagus nerve;C group(Nicotine pretreatment group):induction of SIRS model i... |
| |
| Keywords: | Two-hit Vagotomy Nicotine pretreatment SIRS |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
